: sAHP conductance
NEURON {
SUFFIX sAHP
USEION ca READ ica
USEION k READ ek WRITE ik
RANGE gbar, g, i
GLOBAL ca0, tau, taucadiv, n, kca, cah, a1max, a2, b1, b2
GLOBAL tau1Ref, tau1, tau2, oinf, c1inf, CaRef
}
UNITS {
(molar) = (1/liter)
(mM) = (millimolar)
(mV) = (millivolt)
(mA) = (milliamp)
(S) = (siemens)
(pS) = (picosiemens)
(um) = (micron)
}
PARAMETER {
B = .26 (mM-cm2/mA-ms)
gbar = .0 (pS/um2)
ca0 = .00007 (mM)
tau = 9 (ms)
taucadiv = 1
n = 1
tau1Ref = 200 (ms)
tau2 = 200 (ms)
c1inf = 0.25
oinf = 0.5
CaRef = .002 (mM)
kca = 0.001 (mM)
cah = 0.01 (mM)
}
ASSIGNED {
v (mV)
ek (mV)
ik (mA/cm2)
i (mA/cm2)
ica (mA/cm2)
g (pS/um2)
a1ca (/ms)
a1maxCaRef (/ms)
a1max (/ms/mM)
a1 (/ms/mM)
b1 (/ms)
a2 (/ms)
b2 (/ms)
tau1 (ms)
}
STATE {
ca_i (mM) <1e-5>
c1
o
}
INITIAL {
ca_i = ca0
a2 = -(oinf/((-1 + c1inf)*tau2))
b1 = -(c1inf/((-1 + oinf)*tau1Ref))
b2 = 1/tau2 - a2
a1maxCaRef = 1/tau1Ref - b1
a1max = a1maxCaRef/CaRef
a1ca = (a1max*ca_i)/(1+exp(-(ca_i-cah)/kca))
tau1 = 1/(a1ca + b1)
o = (a2*(-1 + b1*tau1)*tau2)/(-1 + a2*b1*tau1*tau2)
c1 = (b1*tau1*(-1 + a2*tau2))/(-1 + a2*b1*tau1*tau2)
}
BREAKPOINT {
SOLVE state METHOD cnexp
g = gbar*o^n
ik = g*(v - ek)*(1e-4)
i = ik
}
DERIVATIVE state {
ca_i' = -B*ica - taucadiv*(ca_i-ca0)/tau
a1ca = (a1max*ca_i)/(1+exp(-(ca_i-cah)/kca))
c1' = b1*(1 - o) - c1*(a1ca + b1)
o' = a2*(1 - c1) - o*(a2 + b2)
}