/*-------------------------------------------------------------- TEMPLATE FILE FOR DEFINING RETICULAR NEURONS -------------------------------------------- One compartment model and currents derived from: Destexhe, A., Contreras, D., Sejnowski, T.J. and Steriade, M. A model of spindle rhythmicity in the isolated thalamic reticular nucleus. J. Neurophysiol. 72: 803-818, 1994. Destexhe, A., Contreras, D., Steriade, M., Sejnowski, T.J., and Huguenard, J.R. In vivo, in vitro and computational analysis of dendritic calcium currents in thalamic reticular neurons. Journal of Neuroscience 16: 169-185, 1996. Modifications: - passive parameters estimated from simplex - IT2: Q10=2.5, strong conductance for broad bursts - no IK[Ca], no ICAN - Ca++: simple decay only This model is described in detail in: Destexhe, A., Bal, T., McCormick, D.A. and Sejnowski, T.J. Ionic mechanisms underlying synchronized oscillations and propagating waves in a model of ferret thalamic slices. Journal of Neurophysiology 76: 2049-2070, 1996. See also http://www.cnl.salk.edu/~alain , http://cns.fmed.ulaval.ca Alain Destexhe, Salk Institute and Laval University, 1995 --------------------------------------------------------------*/ print " " print " << defining template for one-compartment sRE cell >> " print " " begintemplate sRE // create a new template object public soma create soma[1] // one-compartment of 14260 um2 soma { nseg = 1 diam = 70 L = 64.86 cm=1 } proc init() { local v_potassium, v_sodium v_potassium = -100 // potassium reversal potential v_sodium = 50 // sodium reversal potential soma { Ra = 100 // geometry nseg = 1 diam = 70 L = 64.86 insert pas // leak current e_pas = -90 g_pas = 5e-5 insert hh2 // Hodgin-Huxley INa and IK ek = v_potassium ena = v_sodium vtraub_hh2 = -55 gnabar_hh2 = 0.2 gkbar_hh2 = 0.02 insert it2 // reticular IT current cai = 2.4e-4 cao = 2 eca = 120 shift_it2 = 2 qm_it2 = 2.5 // low q10 qh_it2 = 2.5 gcabar_it2 = 0.003 // strong insert cad // calcium decay depth_cad = 1 taur_cad = 5 cainf_cad = 2.4e-4 kt_cad = 0 // no pump } print " " print "<< sRE: passive, INa, IK, ITs, IAHP and Ca++ decay inserted >>" print " " } endtemplate sRE