//genesis //Net_parameters.g //SP Network Parameters str indataInfoFile = "INPUTDATA_SP/inputInfo.txt" openfile {indataInfoFile} r str indataType = {readfile {indataInfoFile}} float corr_syn_Glu = {readfile {indataInfoFile}} float corr_syn_GABA = {readfile {indataInfoFile}} float upFreq = {readfile {indataInfoFile}} float noiseFreq = {readfile {indataInfoFile}} float maxInputTime = {readfile {indataInfoFile}} int randSeed = {readfile {indataInfoFile}} //int numCells = {readfile {indataInfoFile}} closefile {indataInfoFile} int numCells_SP = 1000 int weight_C_SP =1, weight_C_FS=3 //CLOCKS float simDt=1e-5 //1e-6 needed for voltage clamp float VmOutDt=1e-4 float CaOutDt= 5e-4 float spikeoutdt=1e-3 float maxTime = 2.0 // simulation time float tmax = 2.0 str outputName = "SPnetout" setclock 0 2e-5 // Simulation time step (Second) //setclock 1 5e-4 // time step for graphic output setclock 1 1e-4 // Use the SPRNG random number generator setrand -sprng randseed {{randSeed} + 4680} int inputs /* Neurons will be placed on a two dimensional NX by NY grid, with points SEP_X and SEP_Y apart in the x and y directions. The distance between interacting Spiny projection neurons was recorded to be 264 +- 101 um (mean) but to represent a bigger network a separation of 500 um will be used.- Tunstall but <10 um from Plenz's paper */ //int NX_SP = {round {pow {numCells_SP} 0.3333}} // number of cells = NX*NY int NX_SP = {sqrt {numCells_SP}} // number of cells = NX*NY int NY_SP = NX_SP, NZ_SP = NX_SP float SEP_X_SP = 25e-6 // 25 um Gittis et al float SEP_Y_SP = 25e-6 float SEP_Z_SP = 25e-6 float area_x_SP = {NX_SP}*{SEP_X_SP} float area_y_SP = {NY_SP}*{SEP_Y_SP} float area_z_SP = {NZ_SP}*{SEP_Z_SP} //float syn_weight = 4 // synaptic weight, effectively multiplies gmax float cond_vel = 1 // m/sec - GABA and the Basal Ganglia by Tepper et al //float syn_weight2 = 4 // synaptic weight, effectively multiplies gmax float cond_vel2 = 0.8 // m/sec - GABA and the Basal Ganglia by Tepper et al float prop_delay = {SEP_X_SP}/{cond_vel2} float gmax = 4e-9 float gmax2 = 6e-9 float percDup_SP = 0.1 //0.3 int nDups_a_SP = {ndups_a {percDup_SP} {nAMPA_SP}} int nDups_g_SP = {ndups_g {percDup_SP} {nGABA_SP}} int nUnique_a_SP = {{nAMPA_SP} - {nDups_a_SP}} int nAMPA_SP_D1 = {0.8*{nAMPA_SP}} int nDups_a_SP_D1 = {ndups_a {percDup_SP} {nAMPA_SP_D1}} int nUnique_a_SP_D1 = {{nAMPA_SP_D1} - {nDups_a_SP_D1}} int nUnique_g_SP = {{nGABA_SP} - {nDups_g_SP}} int loops_SP=2, weight_SP_D1=1, weight_SP_D2=1 float origin_x_SP = 0, origin_y_SP = 0 float factor_SP = 95e-6 /* function set_weights(weight) float weight planarweight /network/SPcell[]/soma/spike -fixed {weight} end function set_delays(delay) float delay planardelay /network/SPcell[]/soma/spike -fixed {delay} end function step_tmax echo {NX*NY}" cells dt = "{getclock 0}" tmax = "{maxTime} echo "START: " {getdate} step {maxTime} -time echo "END : " {getdate} end */ //FS Network Parameters str parFile = "parameters.txt" openfile {parFile} r str readGapLine int numGaps = {readfile {parFile}} int nG for (nG=1; nG<{numGaps}+1; nG = {nG}+1) readGapLine = {readfile {parFile} -linemode} addglobal str gapSrc_{nG} {getarg {arglist {readGapLine}} -arg 1} addglobal str gapDest_{nG} {getarg {arglist {readGapLine}} -arg 2} addglobal str gapRes_{nG} {getarg {arglist {readGapLine}} -arg 3} end closefile {parFile} int numCells_FS = 49 // Use the SPRNG random number generator setrand -sprng randseed {{randSeed} + 4680} int inputs /* Neurons will be placed on a two dimensional NX by NY grid, with points SEP_X and SEP_Y apart in the x and y directions. The distance between interacting Spiny projection neurons was recorded to be 264 +- 101 um (mean) but to represent a bigger network a separation of 500 um will be used.- Tunstall but <10 um from Plenz's paper */ int NX_FS = {sqrt {numCells_FS}} // number of cells = NX*NY int NY_FS = NX_FS float SEP_X_FS = 100e-6 // 100 um Gittis et al float SEP_Y_FS = 100e-6 float area_x_FS = {NX_FS}*{SEP_X_FS} float area_y_FS = {NY_FS}*{SEP_Y_FS} /* float syn_weight = 4 // synaptic weight, effectively multiplies gmax float cond_vel = 1 // m/sec - GABA and the Basal Ganglia by Tepper et al float syn_weight2 = 4 // synaptic weight, effectively multiplies gmax float cond_vel2 = 0.8 // m/sec - GABA and the Basal Ganglia by Tepper et al float prop_delay = {SEP_X}/{cond_vel2} float gmax = 4e-9 float gmax2 = 6e-9 */ float percDup_FS = 0.1 int nDups_a_FS = {ndups_a {percDup_FS} {nAMPA_FS}} int nDups_g_FS = {ndups_g {percDup_FS} {nGABA_FS}} int nUnique_a_FS = {{nAMPA_FS} - {nDups_a_FS}} int nUnique_g_FS = {{nGABA_FS} - {nDups_g_FS}} int loops_FS=1, weight_FS=1, weight_FS_D1=8, weight_FS_D2=8 float origin_x_FS = 50e-6, origin_y_FS = 50e-6 float factor_FS = 400e-6 float factor_FS_SP = 300e-6 /* function set_weights(weight) float weight planarweight /network/FScell[]/soma/spike -fixed {weight} end function set_delays(delay) float delay planardelay /network/FScell[]/soma/spike -fixed {delay} end */ /* function step_tmax echo {NX*NY}" cells dt = "{getclock 0}" tmax = "{maxTime} echo "START: " {getdate} step {maxTime} -time echo "END : " {getdate} end */