//genesis /*************************** MS Model, Version 5.2 ********************* **************************** CaL12NOINACT_channel.g ********************* Tom Sheehan tsheeha2@gmu.edu thsheeha@vt.edu 703-538-8361 ****************************************************************************** ******************************************************************************/ function create_CaL12NOINACT str chanName = "CaL12NOINACT_channel" str compPath = "/library" int c float xmin = -0.1 float xmax = 0.05 int xdivs = 3000 float mPower = 1.0 float hPower = 0.0 float increment = 0.00005 float x = -0.1 float surf = 0 float gMax = 5.5610000e-008 float CaL12NOINACT_mTau = 0.0 float CaL12NOINACT_mInf = 0.0 float mvHalfCaL12 = -8.9e-3 float mkCaL12 = -6.7e-3 float theta = 0.0 float beta = 0.0 float beta_exp = 0.0 float mA = 0.0 float mB = 0.0 float qFactCaL12 = {3.0/{CaSlow}} pushe {compPath} create tabchannel {chanName} setfield {chanName} Xpower {mPower} Ypower {hPower} call {chanName} TABCREATE X {xdivs} {xmin} {xmax} for(c = 0; c < {xdivs} + 1; c = c + 1) /**************************** Begin CaL12NOINACT_mTau ********************/ //mA = 0.0398e6*(vMemb + 8.124e-3)./(exp((vMemb + 8.124e-3)/9.005e-3) - 1); //mB = 0.99e3*exp(vMemb/31.4e-3); //CaL12NOINACT_mTau = 1./(mA + mB) / qFactCaL12; theta = 0.0398e6*{ {x} + 8.124e-3} beta = {{x} + 8.124e-3}/9.005e-3 beta_exp = {exp {beta}} beta_exp = beta_exp - 1.0 mA = {{theta}/{beta_exp}} beta = {{x}/31.4e-3} beta_exp = {exp {beta}} mB = 0.99e3*{beta_exp} CaL12NOINACT_mTau = {1.0/{mA + mB}}/{qFactCaL12} setfield {chanName} X_A->table[{c}] {CaL12NOINACT_mTau} /**************************** End CaL12NOINACT_mTau **********************/ /**************************** Begin CaL12NOINACT_mInf ********************/ // CaL12NOINACT_mInf = 1./(1 + exp((vMemb - mvHalfCaL12)/mkCaL12)); beta = {{x} - {mvHalfCaL12}}/{mkCaL12} beta_exp = {exp {beta}} + 1.0 CaL12NOINACT_mInf = 1.0/{beta_exp} setfield {chanName} X_B->table[{c}] {CaL12NOINACT_mInf} /**************************** End CaL12NOINACT_mInf **********************/ x = x + increment end tweaktau {chanName} X create ghk {chanName}GHK setfield {chanName}GHK Cout 2 // Carter & Sabatini 2004 uses 2mM, // Wolf 5mM setfield {chanName}GHK valency 2.0 setfield {chanName}GHK T {TEMPERATURE} setfield {chanName} Gbar {gMax*surf} addmsg {chanName} {chanName}GHK PERMEABILITY Gk pope end