//genesis /*************************** MS Model, Version 5.2 ********************* **************************** CaNNOINACT_channel.g ********************* Tom Sheehan tsheeha2@gmu.edu thsheeha@vt.edu 703-538-8361 ****************************************************************************** ******************************************************************************/ function create_CaNNOINACT str chanName = "CaNNOINACT_channel" str compPath = "/library" int c = 0 float increment = 0.00005 float x = -0.1 int xdivs = 3000 float xmin = -0.1 float xmax = 0.05 float mPower = 1.0 float hPower = 0.0 float mvHalfCaN = -8.7e-3 float mkCaN = -7.4e-3 float mTauCaNNOINACT = 0.0 float mInfCaNNOINACT = 0.0 float theta = 0.0 float beta = 0.0 float beta_exp = 0.0 float mA = 0.0 float mB = 0.0 float surf = 0.0 int qFactCaN = {3.0/{CaSlow}} float gMax = 7.9e-008 pushe {compPath} create tabchannel {chanName} setfield {chanName} Xpower {mPower} Ypower {hPower} call {chanName} TABCREATE X {xdivs} {xmin} {xmax} for(c = 0; c < {xdivs} + 1; c = c + 1) /****************** Begin CaNNOINACT_mTau ********************/ // mA = 0.03856e6*(vMemb + 17.19e-3)./ // (exp((vMemb + 17.19e-3)/15.22e-3)-1); // mB = 0.3842e3*exp(vMemb/23.82e-3); // mTauCaN = (1./(mA + mB)) / qFactCaN; theta = 0.03856e6*{ {x} + 17.19e-3} beta = {{x} + 17.19e-3}/15.22e-3 beta_exp = {exp {beta}} beta_exp = beta_exp - 1.0 mA = {{theta}/{beta_exp}} beta = {{x}/23.82e-3} beta_exp = {exp {beta}} mB = 0.3842e3*{beta_exp} mTauCaNNOINACT = {1/{mA + mB}}/{qFactCaN} setfield {chanName} X_A->table[{c}] {mTauCaNNOINACT} /***************** End CaNNOINACT_mTau ***********************/ /***************** Begin CaNNOINACT_mInf *********************/ // mInfCaN = 1./(1 + exp((vMemb - mvHalfCaN)/mkCaN)); beta = {{x} - {mvHalfCaN}}/{mkCaN} beta_exp = {exp {beta}} + 1.0 mInfCaNNOINACT = 1.0/{beta_exp} setfield {chanName} X_B->table[{c}] {mInfCaNNOINACT} /***************** End CaNNOINACT_mInf ***********************/ x = x + increment end tweaktau {chanName} X create ghk {chanName}GHK setfield {chanName}GHK Cout 2 // Carter & Sabatini 2004 uses 2mM, // Wolf 5mM setfield {chanName}GHK valency 2.0 setfield {chanName}GHK T {TEMPERATURE} setfield {chanName} Gbar {gMax*surf} addmsg {chanName} {chanName}GHK PERMEABILITY Gk pope end