:modified 1/7/2007 by Chris Deister for the GP neuron (to remove some of the background current that existed in Mercer 2007)
NEURON {
SUFFIX sk
USEION k READ ek WRITE ik
USEION ca READ cai
RANGE gbar,gkahp,ik, inf,tau,g
GLOBAL Cq10
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(molar) = (1/liter)
(mM) = (millimolar)
(pS) = (picosiemens)
(um) = (micron)
}
PARAMETER {
gbar = 0 (pS/um2)
n = 4
cai = 50.e-6 (mM)
a0 = 1.3e4 (1/ms-mM-mM-mM-mM) :b0/(1.4e-4^4)
b0 = 0.06 (1/ms) :0.5/(0.100e3), was .5e-2 (1/ms)
celsius = 37(degC)
Cq10 = 3
}
STATE { w }
ASSIGNED {
ik (mA/cm2)
g (pS/um2)
inf
tau (ms)
a (1/ms)
v (mV)
ek (mV)
}
BREAKPOINT {
SOLVE state METHOD cnexp
g = gbar*w
ik = (1e-4)* g*(v-ek)
}
INITIAL {
rate(cai)
w=inf
}
DERIVATIVE state {
rate(cai)
w' = (inf - w)/tau
}
PROCEDURE rate(cai (mM)) {
LOCAL q10
q10 = Cq10^((celsius - 22 (degC))/10 (degC) )
a = a0*cai^4
tau = q10/(a + b0)
inf = a/(a + b0)
}