TITLE K-fast channel from Korngreen and Sakmann 2000
: M.Migliore June 2001
NEURON {
SUFFIX iA
USEION k READ ek WRITE ik
RANGE gbar,ninf,linf,taul,taun
GLOBAL tq,qq, q10,vmin, vmax,tadj,temp
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(pS) = (picosiemens)
(um) = (micron)
}
PARAMETER {
v (mV)
celsius (degC)
Tscale = 10 (degC)
gbar=0.0 (pS/um2)
vhalfn=-47 (mV)
vhalfl=-66 (mV)
kn=29 (mV)
kl=-10 (mV)
qq=5
tq=-55
ek (mV)
vmin = -120 (mV)
vmax = 100 (mV)
temp = 21 (degC) : original temp
q10 = 2.3
}
STATE {
n
l
}
ASSIGNED {
ik (mA/cm2)
ninf
linf
taul (ms)
taun (ms)
tadj
}
INITIAL {
rates(v)
n=ninf
l=linf
}
BREAKPOINT {
SOLVE states METHOD cnexp
ik = (1e-4)*gbar*n^4*l*(v-ek)
}
DERIVATIVE states { : exact when v held constant; integrates over dt step
rates(v)
n' = (ninf - n)/taun
l' = (linf - l)/taul
}
PROCEDURE rates(v (mV)) { :callable from hoc
tadj= q10^((celsius-temp)/Tscale)
ninf = 1/(1 + exp(-(v-vhalfn)/kn))
linf = 1/(1 + exp(-(v-vhalfl)/kl))
taun = (0.34+0.92*exp(-((v+71)/59)^2))/tadj
taul = (8+49*exp(-((v+73)/23)^2))/tadj
}