TITLE HH_Kdr channel for LGMD
: Altered by RBD
UNITS {
(mV) = (millivolt)
(mA) = (milliamp)
}
NEURON {
THREADSAFE
SUFFIX HH_Kdr
USEION k READ ek WRITE ik
: Range variables can differ across neuron (non constants) and there values are accessible
RANGE g, gmax, t1, i
GLOBAL vhalf
}
PARAMETER {
gmax= 0.008 (mho/cm2)
vhalf=-39
vn2=-60
t1=35
t2=0.15
tns=-9
zn=9
}
ASSIGNED {
v (mV)
ek (mV)
ik (mA/cm2)
ninf (/ms)
ntau (/ms)
g (mS/cm2)
i (mA/cm2)
}
STATE {
n
}
BREAKPOINT {
SOLVE states METHOD cnexp
g = gmax*n^4
i = g*(v-ek)
ik = i
}
INITIAL {
settables(v)
n = ninf
}
DERIVATIVE states {
settables(v)
n' = (ninf - n)/ntau
}
UNITSOFF
PROCEDURE settables(v (mV)) {
TABLE ninf, ntau DEPEND vhalf, t1
FROM -100 TO 50 WITH 1500
ninf = 1/(1 + exp((vhalf-v)/zn))
ntau = t1/(1+exp((vn2-v)/tns))*ninf+t2
}
UNITSON