TITLE KdrF channel for LGMD
: RBD
UNITS {
(mV) = (millivolt)
(mA) = (milliamp)
(S) = (siemens)
}
NEURON {
THREADSAFE
SUFFIX KdrF
USEION k READ ek WRITE ik
RANGE gmax, g, t1, t2 : Range variables can differ across neuron (non constants)
GLOBAL vhalf
}
PARAMETER {
gmax= 0.008 (mho/cm2)
vhalf=-39 (mV)
vn2=-40 (mV)
vl=-55 (mV)
t1=2.7 (ms)
t2=0.1 (ms)
tns=7 (mV)
zn=9 (mV)
zl=-9 (mV)
}
ASSIGNED {
v (mV)
ek (mV)
ik (mA/cm2)
ninf
ntau (ms)
g (S/cm2)
}
STATE {
n
}
BREAKPOINT {
SOLVE states METHOD cnexp
g = gmax*n
ik = g*(v-ek)
}
INITIAL {
settables(v)
n = ninf
}
DERIVATIVE states {
settables(v)
n' = (ninf - n)/ntau
}
UNITSOFF
PROCEDURE settables(v (mV)) {
TABLE ninf, ntau DEPEND vhalf, t1
FROM -100 TO 50 WITH 600
ninf = 1/(1 + exp((vhalf-v)/zn))^2
ntau = 2*t1/(1+exp((vn2-v)/tns))/(1+ exp((vl-v)/zl))+t2
:ntau = 4*t1/(1+exp((vn2-v)/tns))*ninf+t2
}
UNITSON