TITLE K-A channel from Klee Ficker and Heinemann
: modified to account for Dax A Current --- M.Migliore Jun 1997
: modified to be used with cvode M.Migliore 2001
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
gkabar=.008 (mho/cm2)
vhalfn=11 (mV)
vhalfl=-56 (mV)
a0l=0.05 (/ms)
a0n=0.05 (/ms)
zetan=-1.5 (degC/mV)
zetal=3 (degC/mV)
gmn=0.55 (1)
gml=1 (1)
lmin=2 (mV)
nmin=0.1 (ms)
pw=-1 (degC/mV)
tq=-40 (mV)
qq=5 (mV)
q10=5 (1)
qtl=1 (mV/ms)
}
NEURON {
THREADSAFE
SUFFIX kap
USEION k READ ek WRITE ik
RANGE gkabar,gka
GLOBAL lmin
}
STATE {
n
l
}
ASSIGNED {
v (mV)
celsius (degC)
ek (mV)
ik (mA/cm2)
ninf (1)
linf (1)
taul (ms)
taun (ms)
gka (mho/cm2)
}
INITIAL {
rates(v)
n=ninf
l=linf
}
BREAKPOINT {
SOLVE states METHOD cnexp
gka = gkabar*n*l
ik = gka*(v-ek)
}
FUNCTION alpn(v(mV)) {
LOCAL zeta
zeta=zetan+pw/(1+exp((v-tq)/qq))
alpn = exp(1.e-3*zeta*(v-vhalfn)*9.648e4/(8.315*(273.16(degC)+celsius)))
}
FUNCTION betn(v(mV)) {
LOCAL zeta
zeta=zetan+pw/(1+exp((v-tq)/qq))
betn = exp(1.e-3*zeta*gmn*(v-vhalfn)*9.648e4/(8.315*(273.16(degC)+celsius)))
}
FUNCTION alpl(v(mV)) {
alpl = exp(1.e-3*zetal*(v-vhalfl)*9.648e4/(8.315*(273.16(degC)+celsius)))
}
FUNCTION betl(v(mV)) {
betl = exp(1.e-3*zetal*gml*(v-vhalfl)*9.648e4/(8.315*(273.16(degC)+celsius)))
}
DERIVATIVE states { : exact when v held constant; integrates over dt step
rates(v)
n' = (ninf - n)/taun
l' = (linf - l)/taul
}
PROCEDURE rates(v (mV)) { :callable from hoc
LOCAL a,qt
qt=q10^((celsius-24(degC))/10(degC))
a = alpn(v)
ninf = 1/(1 + a)
taun = betn(v)/(qt*a0n*(1+a))
if (taun<nmin) {taun=nmin}
a = alpl(v)
linf = 1/(1+ a)
taul = 0.26*(v+50(mV))/qtl
if (taul<lmin/qtl) {taul=lmin/qtl}
}