TITLE Time-dependent (delayed) K+ current
COMMENT
modified From DiFrancesco & Noble 1985 Phil Trans R Soc Lond 307:353-398
modified for Neuron by FE GANNIER
francois.gannier@univ-tours.fr (University of TOURS)
ENDCOMMENT
INCLUDE "Unit.inc"
INCLUDE "Volume.inc"
NEURON {
SUFFIX ikd
USEION k READ ek, ki, ko WRITE ik
RANGE ik, imax
GLOBAL minf, mtau
}
PARAMETER {
imax = 180 (nA)
}
STATE { : x
m
}
ASSIGNED {
v (mV)
celsius (degC) : 37
ik (mA/cm2)
minf
mtau (ms)
ek (mV)
ko (mM)
ki (mM)
}
LOCAL RT
INITIAL {
RT = (1000)*R*(273.15+celsius)
rate(v)
m = minf
}
BREAKPOINT {
SOLVE states METHOD derivimplicit
: original
: ik = (1e-6) * m * imax/S * (ki - ko*exp(-v/25(mV)))/140(mM)
: correction
ik = (1e-06)* m * imax/S * (ki - ko*exp(-v*F/RT))/140(mM)
}
DERIVATIVE states {
rate(v)
m' = (minf - m)/mtau
}
FUNCTION alp(v(mV)) (/ms) {
alp = (0.001)* 0.5(/s)*exp(0.0826(/mV)*(v + 50(mV))) / (1 + exp(0.057(/mV)*(v + 50)))
}
FUNCTION bet(v(mV)) (/ms) {
bet = (0.001)* 1.3(/s)*exp(-0.06(/mV)*(v + 20(mV))) / (1 + exp(-0.04(/mV)*(v + 20 (mV))))
}
: UNITSOFF
PROCEDURE rate(v (mV)) { LOCAL a,b,c :
TABLE minf, mtau FROM -100 TO 100 WITH 200
a = alp(v) b = bet(v)
mtau = 1/(a + b)
minf = a * mtau
}
: UNITSON