TITLE Persistent sodium current (NaP-current)
COMMENT
written for NEURON by Antonios Dougalis, 23 Feb 2015, London, UK
based on voltage clamp data from Dougalis et al., 2017 J Comput Neurosci
ENDCOMMENT
UNITS {
(S) = (siemens)
(mA) = (milliamp)
(mV) = (millivolt)
}
NEURON {
SUFFIX NaP
USEION na READ ena WRITE ina
RANGE gnaPbar,ena,ina
RANGE minf
RANGE tau_m
RANGE vhalfAct,slopeAct
}
PARAMETER {
v (mV)
dt (ms)
gnaPbar = 0.00002 (S/cm2)
ena = 50 (mV)
tau_m = 0.1 (ms)
vhalfAct = -57 (mV)
slopeAct = 3.5
}
STATE {
m
}
ASSIGNED {
ina (mA/cm2)
minf
}
BREAKPOINT {
SOLVE states METHOD cnexp
ina = gnaPbar*m*(v - ena)
}
UNITSOFF
INITIAL {
m = minf
}
DERIVATIVE states {
LOCAL minf
minf = 1/(1 + exp(-(v - vhalfAct)/slopeAct))
m' = (minf-m)/tau_m
}
UNITSON