: Fast Ca2+ & V-dependent K+ channel
: from Durstewitz & Gabriel (2006), Cerebral Cortex
NEURON {
SUFFIX Kc
USEION k READ ki, ko WRITE ik
USEION ca READ cai
RANGE gk, gKcbar
}
UNITS {
(mM) = (milli/liter)
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
cai (mM)
gKcbar= 0.0022 (mho/cm2)
}
ASSIGNED {
v (mV)
ik (mA/cm2)
cinf
ctau (ms)
gk (mho/cm2)
ek (mV)
ki (mM)
ko (mM)
}
STATE {
c
}
INITIAL {
rate(v)
c = cinf
}
BREAKPOINT {
SOLVE states METHOD derivimplicit
gk = gKcbar*c*c
ek = 25*log(ko/ki)
ik = gk*(v-ek)
}
DERIVATIVE states {
rate(v)
c' = (cinf-c)/ctau
}
UNITSOFF
FUNCTION calf(v (mV), cai (mM)) (/ms) {
LOCAL vs, va
vs=v+40*log10(1000*cai)
va=vs+18
if (fabs(va)<1e-04){
calf = -0.0064*(-12-va*0.5)
}
else {
calf = (-0.0064*vs-0.1152)/(-1+exp(-va/12))
}
}
FUNCTION cbet(v (mV), cai (mM))(/ms) {
LOCAL vs
vs=v+40*log10(cai*1000)+152
cbet = 1.7*exp(-vs/30)
}
PROCEDURE rate(v) {
LOCAL csum, ca, cb
ca=calf(v,cai)
cb=cbet(v, cai)
csum = ca+cb
cinf = ca/csum
ctau = 1/csum
if (ctau<1.1) { ctau = 1.1 }
}
UNITSON