//================================================================== // H current (Anomalous rectifier--mixed Na and K current) // HCN1/HCN2 heteromeric channels and HCN2 homomeric channels // Channel model from Chan et al (2004), J Neurosci 24: 9921-32. // Original model from Siegelbaum lab. Wang et al (2002), Neuron 36: // 451-62. Chen et al (2001), JGP 117: 491-504. //================================================================== // --> kinetics for room temperature // HCN1/2 heteromeric channels: float mpower_HCN1 = 1 float V0m_HCN1 = -0.0764 float Km_HCN1 = -0.0033 float taumin_HCN1 = 0 float taumax_HCN1 = 14.5 // actual taumax 3.625 with Q10 adjustment float Ktau1_HCN1 = 0.00656 float Ktau2_HCN1 = -0.00748 float dq10_HCN1 = 4 function make_h_HCN_GP if ({exists h_HCN_GP}) return end create tabchannel h_HCN_GP setfield h_HCN_GP Ek {Eh} Gbar {{G_h_HCN_GP}} \ Xpower {mpower_HCN1} Ypower 0 Zpower 0 float Km = {Km_HCN1} float V0m = {V0m_HCN1} float taumin = {taumin_HCN1} / {dq10_HCN1} float taumax = {taumax_HCN1} / {dq10_HCN1} float Ktau1 = {Ktau1_HCN1} float Ktau2 = {Ktau2_HCN1} float dq10 = {dq10_HCN1} float minf, taum call h_HCN_GP TABCREATE X {xdivs} {xmin} {xmax} x = xmin for (i = 0; i <= {xdivs}; i = i + 1) minf = 1 / (1 + {exp {({V0m} - x) / {Km} }}) taum = {taumin} + (({taumax} - {taumin}) / ({exp {({V0m} - x)/{Ktau1}}} + {exp {({V0m}-x)/{Ktau2}}})) setfield h_HCN_GP X_A->table[{i}] {taum} setfield h_HCN_GP X_B->table[{i}] {minf} x = x + dx end tweaktau h_HCN_GP X call h_HCN_GP TABFILL X 6000 0 setfield h_HCN_GP X_A->calc_mode {NO_INTERP} setfield h_HCN_GP X_B->calc_mode {NO_INTERP} end // HCN2 homomeric channels: float mpower_HCN2 = 1 float V0m_HCN2 = -0.0875 float Km_HCN2 = -0.004 float taumin_HCN2 = 0 float taumax_HCN2 = 25.2 // actual taumax 6.3 with Q10 adjustment float Ktau1_HCN2 = 0.0089 float Ktau2_HCN2 = -0.0082 float dq10_HCN2 = 4 function make_h_HCN2_GP if ({exists h_HCN2_GP}) return end create tabchannel h_HCN2_GP setfield h_HCN2_GP Ek {Eh} Gbar {{G_h_HCN2_GP}} \ Xpower {mpower_HCN2} Ypower 0 Zpower 0 float Km = {Km_HCN2} float V0m = {V0m_HCN2} float taumin = {taumin_HCN2} / {dq10_HCN2} float taumax = {taumax_HCN2} / {dq10_HCN2} float Ktau1 = {Ktau1_HCN2} float Ktau2 = {Ktau2_HCN2} float dq10 = {dq10_HCN2} float minf, taum call h_HCN2_GP TABCREATE X {xdivs} {xmin} {xmax} x = xmin for (i = 0; i <= {xdivs}; i = i + 1) minf = 1 / (1 + {exp {({V0m} - x) / {Km} }}) taum = {taumin} + (({taumax} - {taumin}) / ({exp {({V0m} - x)/{Ktau1}}} + {exp {({V0m} - x)/{Ktau2}}})) setfield h_HCN2_GP X_A->table[{i}] {taum} setfield h_HCN2_GP X_B->table[{i}] {minf} x = x + dx end tweaktau h_HCN2_GP X call h_HCN2_GP TABFILL X 6000 0 setfield h_HCN2_GP X_A->calc_mode {NO_INTERP} setfield h_HCN2_GP X_B->calc_mode {NO_INTERP} end