// GENESIS SETUP FILE silent //load variable parameter values from environment variable if ({getenv GENESIS_PAR_ROW} == "") echo "*********************************************************************" echo "Error: This script needs to read the parameters from the environment " echo " variable GENESIS_PAR_ROW. Set the variable prior to running" echo " the script. Aborting simulation." echo "*********************************************************************" quit end str parrow = {getenv GENESIS_PAR_ROW} echo "Parameter row: " {parrow} int i str tstr, hstr, readcompartment // ************************ RUN-SPECIFIC PARAMS ************************** // Put all parameter settings that will change from run to run here. // MODEL PROPERTIES // mtype: 1 for 9-channel model, 2 for 2-channel (NaK) model int mtype = {getarg {arglist {parrow}} -arg 1} // INITIALIZE BIOPHYSICS VARIABLES. CAN OVERWRITE WITH PARAMS. if ({mtype} == 2) include ../common/biophysics/GP1_active_NaK.g else include ../common/biophysics/GP1_active.g end include ../common/GP1_constants.g include ../common/biophysics/GP1_passive.g include ../common/biophysics/GPchannels.g include ../common/biophysics/GPsyns_params.g /* COMMENT ALL intrinsic model params have now been initialized and set. They can be safely overwritten any time between now and the calling of the make_GP_library function. Once the library has been created, parameter values are set and cannot be changed except with explicit calls to setfield. */ // chanscale_select: 1 for uniform dendritic gNaF, 2 for declining gradient int chanscale_select = {getarg {arglist {parrow}} -arg 2} // scalemin: minimum dendritic gNaF in gradient models is // {initial dendritic gnaf} * {scalemin} float scalemin = 0.01 // Gradients would decline to 1% of somatic gNaF if // the dendrite went far enough. // scaletau: gradient length constant (determines how quickly gNaF falls off // with distance from the soma. Units = microns. float scaletau = {getarg {arglist {parrow}} -arg 3} // SYNAPTIC INPUT float STN_rate = {getarg {arglist {parrow}} -arg 4} float striatum_rate = {getarg {arglist {parrow}} -arg 5} int excscaling = 1 int inhscaling = 1 // scaling parameters: // 0 = no normalization. Just have 1 synapse per compartment, uniform size. // 1 = normalize rate by compartment surface area (typical) // 2 = normalize rate by compartment length // OUTPUT // compartments to store Vm from: //str outputcompsfname = "../common/comptlists/GP1allcompnames.asc" //str outputcompsfname = "../common/comptlists/soma_only.asc" //str outputcompsfname = "../common/comptlists/GP1_spkinit.asc" str outputcompsfname = "../common/comptlists/GP1_outputcomps_20060213.asc" //filename based on variable parameters str basefilename = {mtype} @ "_mtype_" @ \ {chanscale_select} @ "_scaleMeth_" @ \ {scaletau} @ "_sclTau_" @ \ {STN_rate} @ "_HzSTN_" @ \ {striatum_rate} @ "_HzStr_" @ \ "vivo_example" // Local folder into which data will be written str localdir = "data_vivo/" str filename_v = {basefilename} @ "_v.bin" str filename_gSTN = {basefilename} @ "_gAMPA.bin" str filename_gStr = {basefilename} @ "_gGABA.bin" // What will be saved (switches): int save_events = 0 // spike events int save_voltage = 1 // voltage traces int save_gSTN = 0 // All excitatory conductances int save_gStr = 0 // All inhibitory conductances int save_STN_ttabs = 0 // ASCII text lists of excitatory events int save_Str_ttabs = 0 // ASCII text lists of inhibitory events // SIMULATION TIMING float dt = 1e-5 // time step (in seconds) float rundur = 6 // simulation length (in seconds) // NOW CALL SCRIPT TO HANDLE THE DETAILS include setup_vivo_example.g