COMMENT
//****************************//
// Created by Alon Polsky //
// apmega@yahoo.com //
// 2010 //
//****************************//
based on Sun et al 2006
Modified by Robert Egger 2013 to include
normalization of synaptic conductances
ENDCOMMENT
TITLE GABAA synapse activated by the network
NEURON {
POINT_PROCESS gaba_syn
NONSPECIFIC_CURRENT i
RANGE xloc,yloc,tag1,tag2
RANGE gmax,local_v,i
RANGE taudgaba,dgaba,ggaba
RANGE R,D
RANGE risetime,decaytime ,e ,decaygaba
}
PARAMETER {
gmax=.5 (nS)
e= -60.0 (mV)
risetime=1 (ms) :2
decaytime=20(ms) :40
v (mV)
taudgaba=200 (ms)
decaygaba=0.8
xloc=0
yloc=0
tag1=0
tag2=0
}
ASSIGNED {
i (nA)
local_v (mV):local voltage
ggaba
factor : conductance normalization factor
}
STATE {
dgaba
R
D
}
INITIAL {
LOCAL tp
dgaba=1
R=0
D=0
ggaba=0
tp = (risetime*decaytime)/(decaytime - risetime) * log(decaytime/risetime)
factor = -exp(-tp/risetime) + exp(-tp/decaytime)
factor = 1/factor
}
BREAKPOINT {
SOLVE state METHOD cnexp
ggaba=D-R
i=(1e-3)*ggaba*(v-e)
}
NET_RECEIVE(weight) {
state_discontinuity( R, R+ factor*weight*(dgaba))
state_discontinuity( D, D+ factor*weight*(dgaba))
state_discontinuity( dgaba, dgaba* decaygaba)
}
DERIVATIVE state {
R'=-R/risetime
D'=-D/decaytime
dgaba'=(1-dgaba)/taudgaba
}