TITLE I-h channel from Magee 1998 for distal dendrites
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
v (mV)
ehd=-30 (mV)
ghdbar=0.001 (mho/cm2) : must be explicitly def. in hoc
vh=-95 (mV) : must be explicitly def. in hoc
tc : must be explicitly def. in hoc
vhalft=-112 (mV)
a0t=0.0016 (/ms)
zetat=2.2 (1)
gmt=.9 (1)
k=8
}
NEURON {
SUFFIX hd
NONSPECIFIC_CURRENT i
RANGE ghdbar
GLOBAL linf,taul, vh, tc
}
STATE {
l
}
ASSIGNED {
i (mA/cm2)
linf
taul
ghd
}
INITIAL {
rate(v)
l=linf
}
BREAKPOINT {
SOLVE states METHOD cnexp
ghd = ghdbar*l
i = ghd*(v-ehd)
}
DERIVATIVE states { : exact when v held constant; integrates over dt step
rate(v)
l' = (linf - l)/taul
}
FUNCTION alpt(v(mV)) {
alpt = exp(0.0378*zetat*(v-vhalft))
}
FUNCTION bett(v(mV)) {
bett = exp(0.0378*zetat*gmt*(v-vhalft))
}
PROCEDURE rate(v) { :callable from hoc
LOCAL a
linf = 1/(1 + exp((v-vh)/k))
: taul = tc
a = alpt(v)
taul = bett(v)/(a0t*(1+a))
}