TITLE Motoneuron L-type Calcium channels
:
: The parameters for this current come from V. Booth et al. J Neurophysiol 78:3371-3385, 1997
: Iterative equations
:
NEURON {
SUFFIX Llva
NONSPECIFIC_CURRENT ica
RANGE gcaLlvabar, eca, gcaLlva
RANGE m_inf
RANGE theta_m
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
gcaLlvabar = 0.0003 (mho/cm2)
eca = 60 (mV)
tau_m = 20 (ms)
theta_m = -30 (mV)
kappa_m = -6 (mV)
}
STATE {
m
}
ASSIGNED {
v (mV)
dt (ms)
ica (mA/cm2)
m_inf
tadj
gcaLlva (mho/cm2)
}
BREAKPOINT {
SOLVE states METHOD cnexp
gcaLlva = gcaLlvabar * m
ica = gcaLlvabar * m * (v - eca)
}
DERIVATIVE states {
evaluate_fct(v)
m' = (m_inf - m) / tau_m :'
}
UNITSOFF
INITIAL {
:
: Q10 was assumed to be 3 for both currents
:
: tadj = 3.0 ^ ((celsius-36)/ 10 )
evaluate_fct(v)
m = m_inf
}
PROCEDURE evaluate_fct(v(mV)) {
m_inf = 1 / (1 + (Exp((v - theta_m)/ kappa_m))) : / tadj
}
FUNCTION vtrap(x,y) {
if (fabs(x/y) < 1e-6) {
vtrap = y*(1 - x/y/2)
}else{
vtrap = x/(Exp(x/y)-1)
}
}
FUNCTION Exp(x) {
if (x < -100) {
Exp = 0
}else{
Exp = exp(x)
}
}