TITLE Motoneuron Soma channels
:
: Fast Sodium Channels - Soma
NEURON {
SUFFIX NafSm
NONSPECIFIC_CURRENT ina
RANGE gnabar, ena, gna
RANGE m_inf, h_inf
RANGE th , shiftT
RANGE amA, bmA, theta_h
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
gnabar = 0.06 (mho/cm2)
amA = 14 (mV)
bmA = 38 (mV)
th = 30 (ms)
theta_h = 55
kappa_h = 7
ena = 50 (mV)
celsius = 36 (degC)
shiftT = 0 (degC)
vtraub = -10 (mV)
vtraub2 = -70 (mV)
}
STATE {
m h
}
ASSIGNED {
dt (ms)
v (mV)
ina (mA/cm2)
gna (mho/cm2)
m_inf
h_inf
tau_m (ms)
tau_h (ms)
shift
tadj
}
BREAKPOINT {
SOLVE states METHOD cnexp
gna = gnabar * m*m*m*h
ina = gnabar * m*m*m*h * (v - ena)
}
DERIVATIVE states { : exact Hodgkin-Huxley equations
evaluate_fct(v)
m' = (m_inf - m) / tau_m
h' = (h_inf - h) / tau_h
}
UNITSOFF
INITIAL {
: Q10 was assumed to be 3
tadj = 3.0 ^ ((celsius-36-shiftT)/ 10 )
evaluate_fct(v)
m = m_inf
h = h_inf
}
PROCEDURE evaluate_fct(v(mV)) { LOCAL v2, v22, a, b
v2 = v - vtraub : convert to traub convention
v22 = v - vtraub2
a = 0.4*vtrap(amA-v22,5)
b = 0.4*vtrap(v22-bmA,5)
tau_m = (1*tadj) / (a + b)
m_inf = a / (a + b)
tau_h = (th * tadj) / (Exp((v2+50)/15)+Exp(-(v2+50)/16))
h_inf = 1 / (1+Exp((v2+theta_h)/kappa_h))
}
FUNCTION vtrap(x,y) {
if (fabs(x/y) < 1e-6) {
vtrap = y*(1 - x/y/2)
}else{
vtrap = x/(Exp(x/y)-1)
}
}
FUNCTION Exp(x) {
if (x < -100) {
Exp = 0
}else{
Exp = exp(x)
}
}