TITLE Motoneuron N-type Calcium channels
:
: The parameters for this current come from Booth et al. JNP, 1997
:
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
NEURON {
SUFFIX N_Ca
USEION ca READ eca WRITE ica
RANGE gcabar
RANGE m_inf, h_inf
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
: gcabar = .02 (mho/cm2) :This is the original value
gcabar = .0005 (mho/cm2)
eca = 80 (mV)
dt (ms)
tau_m = 4 (ms)
tau_h = 40 (ms)
v (mV)
theta_m = -20 (mV)
kappa_m = -5 (mV)
theta_h = -45 (mV)
kappa_h = 5 (mV)
}
STATE {
m h
}
ASSIGNED {
ica (mA/cm2)
m_inf
h_inf
}
BREAKPOINT {
SOLVE states METHOD cnexp
ica = gcabar * m * m * h * (v - eca)
}
DERIVATIVE states {
evaluate_fct(v)
m' = (m_inf - m) / tau_m
h' = (h_inf - h) / tau_h
}
UNITSOFF
INITIAL {
evaluate_fct(v)
m = m_inf
h = h_inf
}
PROCEDURE evaluate_fct(v(mV)) {
m_inf = 1 / (1 + (Exp((v - theta_m)/ kappa_m)))
h_inf = 1 / (1 + (Exp((v - theta_h)/ kappa_h)))
}
FUNCTION vtrap(x,y) {
if (fabs(x/y) < 1e-6) {
vtrap = y*(1 - x/y/2)
}else{
vtrap = x/(Exp(x/y)-1)
}
}
FUNCTION Exp(x) {
if (x < -100) {
Exp = 0
}else{
Exp = exp(x)
}
}