This is the readme for the models associated with the paper: Eyal G, Verhoog MB, Testa-Silva G, Deitcher Y, Benavides-Piccione R, DeFelipe J, de Kock CPJ, Mansvelder HD, Segev I (2018) Human cortical pyramidal neurons: From spines to spikes via models *Frontiers Cellular Neuroscience* [https://www.frontiersin.org/articles/10.3389/fncel.2018.00181](https://www.frontiersin.org/articles/10.3389/fncel.2018.00181) Consult the README files in the figure subfolders to run the simulations: - ActiveMechanisms/README - Figure1/README.txt - Figure4/README - Figure8/README - NEURON_color_maps/README - FigS3/README - Figure3/README - Figure6/README - Morphs/README - number_of_synapses_to_NMDA_spike/README