load_file("nrngui.hoc")
cvode_active(0)
Vrest = -74
dt = 0.1
gna = 0.2
gk = 0.06
celsius = 22.0 //temperature change not implemented
Rm = 6000
Cm = 2.5
RaAll= 200
RaAx = 50
numaxon=1
numsoma=4
numdend=32
xopen("n500-axon.hoc")
xopen("fixnseg.hoc")
objref stim, apc, b, g, apct, tempo, nil
forsec "axon" {insert pas e_pas=Vrest g_pas = 1/Rm Ra=RaAx cm=Cm}
forsec "soma" {insert pas e_pas=Vrest g_pas = 1/Rm Ra=RaAll cm=Cm}
forsec "dend" {insert pas e_pas=Vrest g_pas = 1/Rm Ra=RaAll cm=Cm}
geom_nseg()
tot=0
forall {tot=tot+nseg}
distance()
maxdist=0
forsec "dend" for(x) {if (distance(x)>maxdist) {maxdist=distance(x)}}
access soma[1]
stim = new IClamp(0.5)
stim.del=10
stim.dur=200
tstop=200
access soma[1]
distance()
apc = new APCount(0.5)
apc.thresh=-20
tempo = new Vector()
soma {
apct = new NetCon(&v(0.5),nil,0,0,0)
apct.record(tempo)
}
forall {
insert ichan2
gnatbar_ichan2=gna
gkfbar_ichan2=gk
gl_ichan2 = 0.0
}
forsec "dend" {gnatbar_ichan2=gna/3
gkfbar_ichan2=gk
}
b = new VBox()
b.intercept(1)
g = new Graph()
g.size(0,tstop,-80,20)
g.xaxis(1)
g.exec_menu("10% Zoom out")
g.addexpr("Granule v_soma","soma.v(0.5)",1,1, 0.2,0.9,2)
xpanel("",1)
xbutton("init & run", "runa()")
xvalue("stim.amp")
xpanel()
b.intercept(0)
b.map()
cvode.re_init()
proc advance() {
fadvance()
g.plot(t)
g.flush()
doNotify()
}
proc init() {
t=0
forall {enat = 55 ekf = -90 eks = -90 v=Vrest}
finitialize(Vrest)
fcurrent()
forall {e_pas=Vrest+(inat_ichan2+ikf_ichan2)/g_pas}
cvode.re_init()
}
proc runa() {
run()
print "stim.amp ", stim.amp, "nA ==> ", ((tempo.size)-9)*(1000/(tempo.x[tempo.size-1]-tempo.x[9])), "Hz "
g.begin()
init()
}