TITLE Potasium C type current for RD Traub, J Neurophysiol 89:909-921, 2003
COMMENT
Modified with simple speed up *2 factor at bottom - Tom Morse
Implemented by Maciej Lazarewicz 2003 (mlazarew@seas.upenn.edu)
ENDCOMMENT
INDEPENDENT { t FROM 0 TO 1 WITH 1 (ms) }
UNITS {
(mV) = (millivolt)
(mA) = (milliamp)
(mM) = (milli/liter)
}
NEURON {
SUFFIX kc_fast
USEION k READ ek WRITE ik
USEION ca READ cai
RANGE gbar, ik
}
PARAMETER {
gbar = 0.0 (mho/cm2)
v (mV) ek (mV)
cai (mM)
}
ASSIGNED {
ik (mA/cm2)
alpha (/ms) beta (/ms)
}
STATE {
m
}
BREAKPOINT {
SOLVE states METHOD cnexp
if( 0.004(/mM) * cai < 1 ) {
ik = gbar * m * 0.004(/mM) * cai * ( v - ek )
}else{
ik = gbar * m * ( v - ek )
}
}
INITIAL {
settables(v)
m = alpha / ( alpha + beta )
m = 0
}
DERIVATIVE states {
settables(v)
m' = alpha * ( 1 - m ) - beta * m
}
UNITSOFF
PROCEDURE settables(v(mV)) {
TABLE alpha, beta FROM -120 TO 40 WITH 641
if( v <= -10.0 ) {
alpha = 2 / 37.95 * ( exp( ( v + 50 ) / 11 - ( v + 53.5 ) / 27 ) )
: Note that there is typo in the paper - missing minus sign in the front of 'v'
beta = 2 * exp( ( - v - 53.5 ) / 27 ) - alpha
}else{
alpha = 2 * exp( ( - v - 53.5 ) / 27 )
beta = 0
}
: speed-up of C kinetics here.
alpha = alpha * 2
beta = beta * 2
}
UNITSON