% Sets up and runs the fsNetwork simulation
% The neuron have different slightly randomized cell parameters
%
% This code is to test if higher input frequency means a relative
% lower decrease of firing frequency due to gap junctions
%
% This code also saves data so the gap junction current can be extracted.
%
% Figure 6B:
% runTenFShigherFreqLessShuntingSaveGJcur.m
% readHigherFreqLessShuntingDataSavedGJcur.m
% makeGJvoltageDiffPlot.m
%
%
% Figure 6C:
% runTenFShigherFreqLessShuntingSaveGJcur.m (same as in 6B)
% readHigherFreqLessShuntingDataSavedGJcur.m
% makeSpikeCenteredGJcurPlot.m
% makeSpikeCenteredGJcurPlotLONGER.m
%
clear all, format compact
tic
% Matlab helper scripts are located here
path(path,'../matlabScripts')
% Genesis model is located here
path(path,'../genesisScripts')
nReps = 2
corrRudolph = 0.5;
upFreqVector = [10/9 20/9 40/9 80/9] %linspace(1,10,10);
%upFreq = 20/9; %10/9
noiseFreq = 1/9;
maxTime = 10 % 100
allowVar = 1 % 0
numCells = 10;
numGJ = 3; % 3*10/2 = 15, 10*9/2 = 45, 15/45 = 1/3 = 33 % coupling
% numGJ = 4 ---> 44% coupling
channelMask = {'A_channel'}
cellVar = 0.5 % 0.2 % 0.1;
lenVar = 0.5 % 0.2 %0.1;
dataFile{1} = 'TenInhomoFS-prim-AllUpstate-HigherFreqLessShunt-saveGJcur';
dataFile{2} = 'TenInhomoFS-nonConRef-AllUpstate-HigherFreqLessShunt-saveGJcur';
dataDir = 'UTDATA/SAVED/TenFS-higherFreqLessShunt-saveGJcur/';
for rep=1:nReps
disp('Pausing for 1 second, press Ctrl+C to abort')
pause(1)
randSeed = floor(sum(clock)*1e5);
% Generate network connections
clear gapSrc gapDest
[gapSrc, gapDest, conMat] = makeFSrandomNetwork(numCells,numGJ);
% figure, showFSnetwork(conMat, randSeed)
conMatFile = strcat([dataDir 'conMat-' num2str(randSeed)], '.mat');
save(conMatFile, 'conMat');
gapSource{1} = gapSrc;
gapSource{2} = []; % Reference case
gapDest{1} = gapDest;
gapDest{2} = []; % Reference case
gapIdNonCon = 2;
% 2e9 ohm = 0.5nS
primGapRes = ones(length(gapSrc),1)*2e9
clear gapRes
gapRes{1} = primGapRes;
gapRes{2} = inf; % Reference case, unconnected
% Generera FS morphologin
makeFSMorph(numCells, cellVar, channelMask, lenVar)
% Generate input!
for freqIdx = 1:length(upFreqVector)
upFreq = upFreqVector(freqIdx);
% Only upstate input
makeAllExternalInputAllUpstate(corrRudolph, upFreq, noiseFreq, ...
max(maxTime,100), allowVar, ...
randSeed, numCells);
for gapIdx = 1:length(gapRes)
disp('Pausing for 1 second, press Ctrl+C to abort')
pause(1)
writeParameters(maxTime,numCells, ...
gapSource{gapIdx}, gapDest{gapIdx}, gapRes{gapIdx}, ...
dataFile{gapIdx});
system('genesis ../genesisScripts/simFsMultiInhomogeneMeasureGJcurrent');
%% Save data
saveFileData = [dataDir dataFile{gapIdx} ...
'-id' num2str(randSeed) ...
'-gapres-' num2str(gapRes{gapIdx}(1)) ...
'-upFreq-' num2str(upFreq) ...
'.data'];
saveFileInfo = strrep(saveFileData,'.data','.info');
system(['cp UTDATA/' dataFile{gapIdx} '.data ' saveFileData]);
system(['cp INDATA/parameters.txt ' saveFileInfo]);
system(['cat INDATA/inputInfo.txt >> ' saveFileInfo]);
end
end
end
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