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<Name>Voltage</Name>
<Value>-100</Value>
<Units>mV</Units>
<DeltaValue>0</DeltaValue>
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<Type>Step</Type>
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<Name>External-K</Name>
<Value>2</Value>
<Units>mM</Units>
<DeltaValue>0</DeltaValue>
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<First>2</First>
<Last>2</Last>
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<Value>100</Value>
<Units>mM</Units>
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<Last>100</Last>
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<Name>DP Inactivation</Name>
<Temperature>34</Temperature>
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<Sweeps>500</Sweeps>
<Time_Sweep_ms>805</Time_Sweep_ms>
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<Variables>
<VariableList>
<VariableAndProtocol>
<Name>Voltage</Name>
<Value>-115</Value>
<Units>mV</Units>
<DeltaValue>0</DeltaValue>
<Steps>
<Step>
<Type>Step</Type>
<First>-115</First>
<Last>-115</Last>
<DeltaFirst>0</DeltaFirst>
<DeltaLast>0</DeltaLast>
<StartTime>100</StartTime>
<DeltaTime>0</DeltaTime>
</Step>
<Step>
<Type>Step</Type>
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<Last>-20</Last>
<DeltaFirst>0</DeltaFirst>
<DeltaLast>0</DeltaLast>
<StartTime>0</StartTime>
<DeltaTime>0.1</DeltaTime>
</Step>
<Step>
<Type>Step</Type>
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<Last>-115</Last>
<DeltaFirst>0</DeltaFirst>
<DeltaLast>0</DeltaLast>
<StartTime>0</StartTime>
<DeltaTime>0</DeltaTime>
</Step>
<Step>
<Type>Step</Type>
<First>70</First>
<Last>70</Last>
<DeltaFirst>0</DeltaFirst>
<DeltaLast>0</DeltaLast>
<StartTime>100</StartTime>
<DeltaTime>0</DeltaTime>
</Step>
<Step>
<Type>Step</Type>
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<DeltaFirst>0</DeltaFirst>
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<DeltaTime>0</DeltaTime>
</Step>
</Steps>
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<VariableAndProtocol>
<Name>External-K</Name>
<Value>2</Value>
<Units>mM</Units>
<DeltaValue>0</DeltaValue>
<Steps>
<Step>
<Type>Step</Type>
<First>2</First>
<Last>2</Last>
<DeltaFirst>0</DeltaFirst>
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<VariableAndProtocol>
<Name>Internal-K</Name>
<Value>100</Value>
<Units>mM</Units>
<DeltaValue>0</DeltaValue>
<Steps>
<Step>
<Type>Step</Type>
<First>100</First>
<Last>100</Last>
<DeltaFirst>0</DeltaFirst>
<DeltaLast>0</DeltaLast>
<StartTime>1000</StartTime>
<DeltaTime>0</DeltaTime>
</Step>
</Steps>
</VariableAndProtocol>
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<SimulationMethod>QMatrix</SimulationMethod>
<NChannels>1000</NChannels>
<SimulationType>IonicCurrent</SimulationType>
<AddNoise>false</AddNoise>
<NoiseStandardDeviation>0.1</NoiseStandardDeviation>
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<Name>SP Inactivation</Name>
<Temperature>20</Temperature>
<ExperimentType>CurrentVsTime</ExperimentType>
<Sweeps>1</Sweeps>
<Time_Sweep_ms>1200</Time_Sweep_ms>
<SampleInterval_us>100</SampleInterval_us>
<SampleType>NSamples</SampleType>
<SamplesSweep>1001</SamplesSweep>
<InitialProbabilities>
<InitialSweepState>SteadyState</InitialSweepState>
<IntervalBetweenSweeps>1000</IntervalBetweenSweeps>
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<SchemeInitialStatesProbabilities>
<GateName>Scheme</GateName>
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<Variables>
<VariableList>
<VariableAndProtocol>
<Name>Voltage</Name>
<Value>-100</Value>
<Units>mV</Units>
<DeltaValue>0</DeltaValue>
<Steps>
<Step>
<Type>Step</Type>
<First>-110</First>
<Last>-110</Last>
<DeltaFirst>0</DeltaFirst>
<DeltaLast>0</DeltaLast>
<StartTime>100</StartTime>
<DeltaTime>0</DeltaTime>
</Step>
<Step>
<Type>Step</Type>
<First>-20</First>
<Last>-20</Last>
<DeltaFirst>0</DeltaFirst>
<DeltaLast>0</DeltaLast>
<StartTime>1000</StartTime>
<DeltaTime>0</DeltaTime>
</Step>
<Step>
<Type>Step</Type>
<First>-110</First>
<Last>-110</Last>
<DeltaFirst>0</DeltaFirst>
<DeltaLast>0</DeltaLast>
<StartTime>100</StartTime>
<DeltaTime>0</DeltaTime>
</Step>
</Steps>
</VariableAndProtocol>
<VariableAndProtocol>
<Name>External-K</Name>
<Value>2</Value>
<Units>mM</Units>
<DeltaValue>0</DeltaValue>
<Steps>
<Step>
<Type>Step</Type>
<First>2</First>
<Last>2</Last>
<DeltaFirst>0</DeltaFirst>
<DeltaLast>0</DeltaLast>
<StartTime>1000</StartTime>
<DeltaTime>0</DeltaTime>
</Step>
</Steps>
</VariableAndProtocol>
<VariableAndProtocol>
<Name>Internal-K</Name>
<Value>100</Value>
<Units>mM</Units>
<DeltaValue>0</DeltaValue>
<Steps>
<Step>
<Type>Step</Type>
<First>100</First>
<Last>100</Last>
<DeltaFirst>0</DeltaFirst>
<DeltaLast>0</DeltaLast>
<StartTime>1000</StartTime>
<DeltaTime>0</DeltaTime>
</Step>
</Steps>
</VariableAndProtocol>
</VariableList>
</Variables>
<SimulationMethod>QMatrix</SimulationMethod>
<NChannels>1000</NChannels>
<SimulationType>IonicCurrent</SimulationType>
<AddNoise>false</AddNoise>
<NoiseStandardDeviation>0.1</NoiseStandardDeviation>
</ExperimentBase>
<ExperimentBase d4p1:type="ExperimentExpressionVsX" xmlns:d4p1="http://www.w3.org/2001/XMLSchema-instance">
<Name>SSI</Name>
<Temperature>34</Temperature>
<ExperimentType>SteadyStateExpressionVsX</ExperimentType>
<Variables>
<VariableList>
<VariableAndDelta>
<Name>Voltage</Name>
<Value>0</Value>
<Units>mV</Units>
<DeltaValue>0</DeltaValue>
</VariableAndDelta>
<VariableAndDelta>
<Name>External-K</Name>
<Value>100</Value>
<Units>mM</Units>
<DeltaValue>0</DeltaValue>
</VariableAndDelta>
<VariableAndDelta>
<Name>Internal-K</Name>
<Value>100</Value>
<Units>mM</Units>
<DeltaValue>0</DeltaValue>
</VariableAndDelta>
</VariableList>
</Variables>
<Sweeps>1</Sweeps>
<SamplesSweep>300</SamplesSweep>
<SelectedVariable>Voltage</SelectedVariable>
<StartValue>-100</StartValue>
<FinalValue>100</FinalValue>
<Expression>C0+C1+C2+C3+C4+C5+O</Expression>
</ExperimentBase>
</List>
</ExperimentList>
<IndexOfSelectedExperiment>2</IndexOfSelectedExperiment>
<Description>
<string />
<string />
<string>Beck, E.J., M. Bowlby, W.F. An, K.J. Rhodes, and M. Covarrubias. 2002.</string>
<string> Remodeling inactivation gating of Kv4 channels by KChIP-1, a small-molecular-weight calcium binding protein. J. Physiol. 538:691-706. </string>
</Description>
<Channel d2p1:type="ChannelScheme" xmlns:d2p1="http://www.w3.org/2001/XMLSchema-instance">
<Name>Channel</Name>
<IonicCurrentList>
<IonicCurrentBase d2p1:type="OhmicCurrent">
<Ion>
<Name>K</Name>
<Type>Ion</Type>
<Valence>1</Valence>
</Ion>
<Conductance>10</Conductance>
</IonicCurrentBase>
</IonicCurrentList>
<Scheme>
<Name>Scheme</Name>
<SchemeID>620486</SchemeID>
<LayersToShow>
<LayerA>0</LayerA>
<LayerB>0</LayerB>
</LayersToShow>
<TransitionCollection>
<TransitionView d2p1:type="TransitionViewAB">
<Transition d2p1:type="TransitionAB">
<StateA>C0</StateA>
<StateB>C1</StateB>
<Activated>true</Activated>
<RateA>4*a</RateA>
<RateB>b</RateB>
</Transition>
</TransitionView>
<TransitionView d2p1:type="TransitionViewAB">
<Transition d2p1:type="TransitionAB">
<StateA>C1</StateA>
<StateB>C2</StateB>
<Activated>true</Activated>
<RateA>3*a</RateA>
<RateB>2*b</RateB>
</Transition>
</TransitionView>
<TransitionView d2p1:type="TransitionViewAB">
<Transition d2p1:type="TransitionAB">
<StateA>C2</StateA>
<StateB>C3</StateB>
<Activated>true</Activated>
<RateA>2*a</RateA>
<RateB>3*b</RateB>
</Transition>
</TransitionView>
<TransitionView d2p1:type="TransitionViewAB">
<Transition d2p1:type="TransitionAB">
<StateA>C3</StateA>
<StateB>C4</StateB>
<Activated>true</Activated>
<RateA>a</RateA>
<RateB>4*b</RateB>
</Transition>
</TransitionView>
<TransitionView d2p1:type="TransitionViewAB">
<Transition d2p1:type="TransitionAB">
<StateA>C4</StateA>
<StateB>C5</StateB>
<Activated>true</Activated>
<RateA>c</RateA>
<RateB>d</RateB>
</Transition>
</TransitionView>
<TransitionView d2p1:type="TransitionViewAB">
<Transition d2p1:type="TransitionAB">
<StateA>C5</StateA>
<StateB>O</StateB>
<Activated>true</Activated>
<RateA>kco</RateA>
<RateB>koc</RateB>
</Transition>
</TransitionView>
<TransitionView d2p1:type="TransitionViewAB">
<Transition d2p1:type="TransitionAB">
<StateA>C0</StateA>
<StateB>I0</StateB>
<Activated>true</Activated>
<RateA>kci*f^4</RateA>
<RateB>kic/(f^4)</RateB>
</Transition>
</TransitionView>
<TransitionView d2p1:type="TransitionViewAB">
<Transition d2p1:type="TransitionAB">
<StateA>C1</StateA>
<StateB>I1</StateB>
<Activated>true</Activated>
<RateA>kci*f^3</RateA>
<RateB>kic/f^3</RateB>
</Transition>
</TransitionView>
<TransitionView d2p1:type="TransitionViewAB">
<Transition d2p1:type="TransitionAB">
<StateA>C2</StateA>
<StateB>I2</StateB>
<Activated>true</Activated>
<RateA>kci*f^2</RateA>
<RateB>kic/(f^2)</RateB>
</Transition>
</TransitionView>
<TransitionView d2p1:type="TransitionViewAB">
<Transition d2p1:type="TransitionAB">
<StateA>C3</StateA>
<StateB>I3</StateB>
<Activated>true</Activated>
<RateA>kci*f</RateA>
<RateB>kic/f</RateB>
</Transition>
</TransitionView>
<TransitionView d2p1:type="TransitionViewAB">
<Transition d2p1:type="TransitionAB">
<StateA>C4</StateA>
<StateB>I4</StateB>
<Activated>true</Activated>
<RateA>kci</RateA>
<RateB>kic</RateB>
</Transition>
</TransitionView>
<TransitionView d2p1:type="TransitionViewAB">
<Transition d2p1:type="TransitionAB">
<StateA>C5</StateA>
<StateB>I5</StateB>
<Activated>true</Activated>
<RateA>kci*g</RateA>
<RateB>kic*g</RateB>
</Transition>
</TransitionView>
<TransitionView d2p1:type="TransitionViewAB">
<Transition d2p1:type="TransitionAB">
<StateA>I0</StateA>
<StateB>I1</StateB>
<Activated>true</Activated>
<RateA>4*a/f</RateA>
<RateB>b*f</RateB>
</Transition>
</TransitionView>
<TransitionView d2p1:type="TransitionViewAB">
<Transition d2p1:type="TransitionAB">
<StateA>I1</StateA>
<StateB>I2</StateB>
<Activated>true</Activated>
<RateA>3*a/f</RateA>
<RateB>2*b*f</RateB>
</Transition>
</TransitionView>
<TransitionView d2p1:type="TransitionViewAB">
<Transition d2p1:type="TransitionAB">
<StateA>I2</StateA>
<StateB>I3</StateB>
<Activated>true</Activated>
<RateA>2*a/f</RateA>
<RateB>3*b*f</RateB>
</Transition>
</TransitionView>
<TransitionView d2p1:type="TransitionViewAB">
<Transition d2p1:type="TransitionAB">
<StateA>I3</StateA>
<StateB>I4</StateB>
<Activated>true</Activated>
<RateA>a/f</RateA>
<RateB>4*b*f</RateB>
</Transition>
</TransitionView>
<TransitionView d2p1:type="TransitionViewAB">
<Transition d2p1:type="TransitionAB">
<StateA>I4</StateA>
<StateB>I5</StateB>
<Activated>true</Activated>
<RateA>c*g</RateA>
<RateB>d/g</RateB>
</Transition>
</TransitionView>
<TransitionView d2p1:type="TransitionViewAB">
<Transition d2p1:type="TransitionAB">
<StateA>O</StateA>
<StateB>I6</StateB>
<Activated>true</Activated>
<RateA>koi</RateA>
<RateB>kio</RateB>
</Transition>
</TransitionView>
<TransitionView d2p1:type="TransitionViewAB">
<Transition d2p1:type="TransitionAB">
<StateA>I6</StateA>
<StateB>I7</StateB>
<Activated>true</Activated>
<RateA>kii2</RateA>
<RateB>ki2i</RateB>
</Transition>
</TransitionView>
</TransitionCollection>
<SchemeFunctionsList>
<FunctionBase d2p1:type="ExponentialFRTFunction">
<Name>a</Name>
<Type>ExponentialFRT</Type>
<NumberParameters>2</NumberParameters>
<P>
<double>7000</double>
<double>0.315646648</double>
</P>
</FunctionBase>
<FunctionBase d2p1:type="ExponentialFRTFunction">
<Name>b</Name>
<Type>ExponentialFRT</Type>
<NumberParameters>2</NumberParameters>
<P>
<double>90</double>
<double>-2.062276</double>
</P>
</FunctionBase>
<FunctionBase d2p1:type="ExponentialFRTFunction">
<Name>c</Name>
<Type>ExponentialFRT</Type>
<NumberParameters>2</NumberParameters>
<P>
<double>1012.16107</double>
<double>0.500095665</double>
</P>
</FunctionBase>
<FunctionBase d2p1:type="ExponentialFRTFunction">
<Name>d</Name>
<Type>ExponentialFRT</Type>
<NumberParameters>2</NumberParameters>
<P>
<double>2498.881</double>
<double>-1.15446687</double>
</P>
</FunctionBase>
<FunctionBase d2p1:type="ExponentialFRTFunction">
<Name>kco</Name>
<Type>ExponentialFRT</Type>
<NumberParameters>2</NumberParameters>
<P>
<double>7690.49072</double>
<double>0.05502051</double>
</P>
</FunctionBase>
<FunctionBase d2p1:type="ExponentialFRTFunction">
<Name>koc</Name>
<Type>ExponentialFRT</Type>
<NumberParameters>2</NumberParameters>
<P>
<double>4385.62354</double>
<double>-0.07092366</double>
</P>
</FunctionBase>
<FunctionBase d2p1:type="ConstantFunction">
<Name>kci</Name>
<Type>Constant</Type>
<NumberParameters>1</NumberParameters>
<P>
<double>121.900093</double>
</P>
</FunctionBase>
<FunctionBase d2p1:type="ConstantFunction">
<Name>kic</Name>
<Type>Constant</Type>
<NumberParameters>1</NumberParameters>
<P>
<double>1.7935468</double>
</P>
</FunctionBase>
<FunctionBase d2p1:type="ConstantFunction">
<Name>f</Name>
<Type>Constant</Type>
<NumberParameters>1</NumberParameters>
<P>
<double>0.27713</double>
</P>
</FunctionBase>
<FunctionBase d2p1:type="ConstantFunction">
<Name>g</Name>
<Type>Constant</Type>
<NumberParameters>1</NumberParameters>
<P>
<double>1.0131</double>
</P>
</FunctionBase>
<FunctionBase d2p1:type="ConstantFunction">
<Name>koi</Name>
<Type>Constant</Type>
<NumberParameters>1</NumberParameters>
<P>
<double>515</double>
</P>
</FunctionBase>
<FunctionBase d2p1:type="ConstantFunction">
<Name>kio</Name>
<Type>Constant</Type>
<NumberParameters>1</NumberParameters>
<P>
<double>44</double>
</P>
</FunctionBase>
<FunctionBase d2p1:type="ConstantFunction">
<Name>kii2</Name>
<Type>Constant</Type>
<NumberParameters>1</NumberParameters>
<P>
<double>150</double>
</P>
</FunctionBase>
<FunctionBase d2p1:type="ConstantFunction">
<Name>ki2i</Name>
<Type>Constant</Type>
<NumberParameters>1</NumberParameters>
<P>
<double>33</double>
</P>
</FunctionBase>
</SchemeFunctionsList>
<StatesList>
<State>
<Name>C0</Name>
<StateID>425301</StateID>
<Activated>true</Activated>
<Charge>0</Charge>
<color>SteelBlue</color>
<Type>Closed</Type>
<GatingValue>0</GatingValue>
<Position>
<X>50</X>
<Y>40</Y>
</Position>
<ZOrder>0</ZOrder>
</State>
<State>
<Name>C1</Name>
<StateID>620486</StateID>
<Activated>true</Activated>
<Charge>2.377922648</Charge>
<color>SteelBlue</color>
<Type>Closed</Type>
<GatingValue>0</GatingValue>
<Position>
<X>180</X>
<Y>40</Y>
</Position>
<ZOrder>0</ZOrder>
</State>
<State>
<Name>C2</Name>
<StateID>347756</StateID>
<Activated>true</Activated>
<Charge>4.755845296</Charge>
<color>SteelBlue</color>
<Type>Closed</Type>
<GatingValue>0</GatingValue>
<Position>
<X>300</X>
<Y>40</Y>
</Position>
<ZOrder>0</ZOrder>
</State>
<State>
<Name>C3</Name>
<StateID>599067</StateID>
<Activated>true</Activated>
<Charge>7.1337679440000006</Charge>
<color>SteelBlue</color>
<Type>Closed</Type>
<GatingValue>0</GatingValue>
<Position>
<X>420</X>
<Y>40</Y>
</Position>
<ZOrder>0</ZOrder>
</State>
<State>
<Name>C4</Name>
<StateID>94900</StateID>
<Activated>true</Activated>
<Charge>9.511690592</Charge>
<color>SteelBlue</color>
<Type>Closed</Type>
<GatingValue>0</GatingValue>
<Position>
<X>540</X>
<Y>40</Y>
</Position>
<ZOrder>0</ZOrder>
</State>
<State>
<Name>O</Name>
<StateID>535759</StateID>
<Activated>true</Activated>
<Charge>11.292197297000001</Charge>
<color>SteelBlue</color>
<Type>Open</Type>
<GatingValue>1</GatingValue>
<Position>
<X>740</X>
<Y>40</Y>
</Position>
<ZOrder>0</ZOrder>
</State>
<State>
<Name>C5</Name>
<StateID>213408</StateID>
<Activated>true</Activated>
<Charge>11.166253127000001</Charge>
<color>SteelBlue</color>
<Type>Closed</Type>
<GatingValue>0</GatingValue>
<Position>
<X>630</X>
<Y>40</Y>
</Position>
<ZOrder>0</ZOrder>
</State>
<State>
<Name>I0</Name>
<StateID>906796</StateID>
<Activated>true</Activated>
<Charge>0</Charge>
<color>SteelBlue</color>
<Type>Closed</Type>
<GatingValue>0</GatingValue>
<Position>
<X>50</X>
<Y>130</Y>
</Position>
<ZOrder>0</ZOrder>
</State>
<State>
<Name>I1</Name>
<StateID>933019</StateID>
<Activated>true</Activated>
<Charge>2.377922648</Charge>
<color>SteelBlue</color>
<Type>Closed</Type>
<GatingValue>0</GatingValue>
<Position>
<X>180</X>
<Y>130</Y>
</Position>
<ZOrder>0</ZOrder>
</State>
<State>
<Name>I2</Name>
<StateID>3805</StateID>
<Activated>true</Activated>
<Charge>4.755845296</Charge>
<color>SteelBlue</color>
<Type>Closed</Type>
<GatingValue>0</GatingValue>
<Position>
<X>300</X>
<Y>130</Y>
</Position>
<ZOrder>0</ZOrder>
</State>
<State>
<Name>I3</Name>
<StateID>414236</StateID>
<Activated>true</Activated>
<Charge>7.1337679440000006</Charge>
<color>SteelBlue</color>
<Type>Closed</Type>
<GatingValue>0</GatingValue>
<Position>
<X>420</X>
<Y>130</Y>
</Position>
<ZOrder>0</ZOrder>
</State>
<State>
<Name>I4</Name>
<StateID>222974</StateID>
<Activated>true</Activated>
<Charge>9.511690592</Charge>
<color>SteelBlue</color>
<Type>Closed</Type>
<GatingValue>0</GatingValue>
<Position>
<X>540</X>
<Y>130</Y>
</Position>
<ZOrder>0</ZOrder>
</State>
<State>
<Name>I5</Name>
<StateID>934360</StateID>
<Activated>true</Activated>
<Charge>11.166253127000001</Charge>
<color>SteelBlue</color>
<Type>Closed</Type>
<GatingValue>0</GatingValue>
<Position>
<X>630</X>
<Y>130</Y>
</Position>
<ZOrder>0</ZOrder>
</State>
<State>
<Name>I6</Name>
<StateID>254171</StateID>
<Activated>true</Activated>
<Charge>11.292197297000001</Charge>
<color>SteelBlue</color>
<Type>Closed</Type>
<GatingValue>0</GatingValue>
<Position>
<X>740</X>
<Y>130</Y>
</Position>
<ZOrder>0</ZOrder>
</State>
<State>
<Name>I7</Name>
<StateID>511429</StateID>
<Activated>true</Activated>
<Charge>11.292197297000001</Charge>
<color>SteelBlue</color>
<Type>Closed</Type>
<GatingValue>0</GatingValue>
<Position>
<X>740</X>
<Y>220</Y>
</Position>
<ZOrder>0</ZOrder>
</State>
</StatesList>
<NGates>1</NGates>
</Scheme>
</Channel>
</ChannelProject>