This code is based on the model published by Dyhrfjeld and available at http://senselab.med.yale.edu/ModelDB/ShowModel.asp?model=93349. The original text of its README file is now in README-Dyhrfjeld. The code of this dir is self-contained. The tabulated channels are in the channels subdirectory, and should be machine-independent. If not, the tables should be recreated. This can be done by starting genesis, and then using > include defaults > include L5P_const.g > include L5P_chans_Temp.g That should do it. The Dyhrfjeld model has been extended and modified in several ways, and some of these changes are reflected in the file names used. - The temperature is now 37 degrees (instead of 32). - A 20-compartmental axon has been added. - Synaptic channels have been added (although NMDA-type and GABAB-type channels were not used for the paper). - Afferent fibres have been created and connected to the synaptic channels. To account for potential differences in the density of inputs along the axis of the neuron and depth of the cortex (layers), a depth profile can be defined for their strengts (see Firing_rate_profile.g). All fibres are Poisson processes and their instantaneous spike rate can be changed over time as follows: - the spike rate of subcortical fibres is modulated by an additional point process with an exponential impulse response, as described by Harsch and Robinson (Harsch-Robinson_modulation.g); - the spike rate of intracolumnar feedback fibres is modulated by the filtered output of the neuron itself. A few control scripts (test_position.g, nsynapses.g) allow you to record some parameters of the model. To simulate this neuron, please type (from within this dir) genesis L5P37C.g