: HH Low TEA-sensitive Purkinje potassium current
: FORREST MD (2014) Two Compartment Model of the Cerebellar Purkinje Neuron
NEURON {
SUFFIX kpkj2
USEION k READ ek WRITE ik
RANGE gkbar
GLOBAL ninf, ntau
}
UNITS {
(mV) = (millivolt)
(mA) = (milliamp)
}
PARAMETER {
v (mV)
gkbar = .002 (mho/cm2)
nivh = -24 (mV)
nik = 20.4
ek
Q10 = 3 (1)
Q10TEMP = 22 (degC)
}
ASSIGNED {
ik
ninf
ntau (ms)
celsius (degC)
qt (1)
}
STATE {
n
}
INITIAL {
rates(v)
n = ninf
: qt = Q10^((celsius-Q10TEMP)/10)
qt = 1
}
BREAKPOINT {
SOLVE states METHOD cnexp
ik = gkbar * n^4 * (v - ek)
}
DERIVATIVE states {
rates(v)
n' = (ninf - n) / ntau
}
PROCEDURE rates(Vm (mV)) {
LOCAL v
v = Vm + 11 : Account for Junction Potential
ninf = 1/(1+exp(-(v-nivh)/nik))
ntau = (1000 * ntau_func(v)) / qt
}
FUNCTION ntau_func(v (mV)) {
if (v < -20) {
ntau_func = .000688 + 1/(exp((v+64.2)/6.5)+exp((v-141.5)/-34.8))
} else {
ntau_func = .00016 + .0008*exp(-.0267 * v)
}
}