NEURON {
SUFFIX kv2_gp
USEION k READ ek WRITE ik
RANGE g, ik, an, bn, gbar
GLOBAL a0, a1, ah, ac, b0, bc, Cq10
}
UNITS {
(mV) = (millivolt)
(mA) = (milliamp)
(S) = (siemens)
}
PARAMETER {
gbar = 1 (S/cm2)
celsius (degC)
Cq10 = 3
a0 = 100.74 (1/ms)
a1 = 0.612 (1/ms-mV)
ah = -84.51 (mV)
ac = -11.84 (mV)
b0 = 0.0051 (1/ms)
bc = 22.02 (mV)
}
ASSIGNED {
v (mV)
ek (mV)
g (S/cm2)
ik (mA/cm2)
an (1/ms)
bn (1/ms)
kf1 (1/ms)
kb1 (1/ms)
kf2 (1/ms)
kb2 (1/ms)
kf3 (1/ms)
kb3 (1/ms)
kf4 (1/ms)
kb4 (1/ms)
}
STATE {
c1
c2
c3
c4
o
}
BREAKPOINT {
SOLVE kin METHOD sparse
g = gbar*o
ik = g*(v-ek)
}
INITIAL {
SOLVE kin STEADYSTATE sparse
}
KINETIC kin{
rates(v)
~ c4 <-> c3 (kf1,kb1)
~ c3 <-> c2 (kf2,kb2)
~ c2 <-> c1 (kf3,kb3)
~ c1 <-> o (kf4,kb4)
CONSERVE c4+c3+c2+c1+o=1
}
PROCEDURE rates(v(mV)) {LOCAL q10
q10 = Cq10^((celsius-22 (degC))/10 (degC))
an = q10*(a0 - a1 *v)/(exp((ah+v)/ac) - 1)
bn = q10*(b0 )/(exp(v/bc))
kf1 = 4*an
kb1 = bn
kf2 = 3*an
kb2 = 2*bn
kf3 = 2*an
kb3 = 3*bn
kf4 = an
kb4 = 4*bn
}