TITLE inas :Transient sodium current in the interneuron soma
NEURON {
SUFFIX inas
USEION na READ ena WRITE ina
RANGE gna, ina, qna
}
UNITS {
(mV) = (millivolt)
(mA) = (milliamp)
PI = (pi) (1)
FARADAY = 96485.309 (coul/mole)
}
INDEPENDENT {t FROM 0 TO 1 WITH 100 (ms)}
PARAMETER {
celsius=32 (degC)
gna=1e-3 (mho/cm2)
}
ASSIGNED {
ina (mA/cm2)
v (mV)
ena (mV)
diam (um)
}
STATE { ma mb ha hb qna }
BREAKPOINT {
SOLVE nastate METHOD sparse
ina = gna*ma*ma*ma*ha*(v-ena)
}
INITIAL {
ma=m_inf(v)
ha=h_inf(v)
mb=1-ma
hb=1-ha
qna = 0
ina = gna*ma*ma*ma*ha*(v-ena)
}
LOCAL a1, a2, b1, b2
KINETIC nastate {
a1 = m_a(v)
a2 = m_b(v)
b1 = h_a(v)
b2 = h_b(v)
~ mb <-> ma (a1, a2)
~ hb <-> ha (b1, b2)
CONSERVE ma + mb = 1
CONSERVE ha + hb = 1
COMPARTMENT diam*diam*PI/4 { qna }
~ qna << (-ina*PI*diam*(1e4)/FARADAY)
}
FUNCTION m_a(v(mV)) {
TABLE FROM -150 TO 150 WITH 301
m_a=0.8*(17.2-v-60)/(exp((17.2-v-60)/4)-1)
}
FUNCTION m_b(v(mV)) {
TABLE FROM -150 TO 150 WITH 301
m_b=0.7*(v-42.2+60)/(exp((v-42.2+60)/5)-1)
}
FUNCTION h_a(v(mV)) {
TABLE FROM -150 TO 150 WITH 301
h_a = 0.32*exp((42-v-60)/18)
}
FUNCTION h_b(v(mV)) {
TABLE FROM -150 TO 150 WITH 301
h_b = 10/(1+exp((42-v-60)/5))
}
FUNCTION m_inf(v(mV)) {
m_inf = m_a(v)/(m_a(v)+m_b(v))
}
FUNCTION h_inf(v(mV)) {
h_inf = h_a(v)/(h_a(v)+h_b(v))
}