// processes and functions
//fixing nseg number of compartments for the spatial discretization
// these are reasonable values for most models
freq = 100 // Hz, frequency at which AC length constant will be computed
d_lambda = 0.1
func lambda_f() { local i, x1, x2, d1, d2, lam
if (n3d() < 2) {
return 1e5*sqrt(diam/(4*PI*$1*user_Ra*user_cm))
}
// above was too inaccurate with large variation in 3d diameter
// so now we use all 3-d points to get a better approximate lambda
x1 = arc3d(0)
d1 = diam3d(0)
lam = 0
for i=1, n3d()-1 {
x2 = arc3d(i)
d2 = diam3d(i)
lam += (x2 - x1)/sqrt(d1 + d2)
x1 = x2 d1 = d2
}
// length of the section in units of lambda
lam *= sqrt(2) * 1e-5*sqrt(4*PI*$1*user_Ra*user_cm)
return L/lam
}
//initializing the simulation
proc init(){
forall{
for(x,0){
Ra = user_Ra
v = 0
cm = user_cm
g_pas = user_g_pas
e_pas = user_e_pas
v_init = 0
}
}
setNseg()
finitialize(v_init)
if (cvode.active()) {
cvode.re_init()
} else {
fcurrent()
}
frecord_init()
}
proc setNseg(){
soma area(0.5) // make sure diam reflects 3d points
forsec all_1 {
nseg = int((L/(d_lambda*lambda_f(freq))+0.9)/2)*2 + 1
}
}
//Setting dt
proc setdt() {local Dt, dtnew
if (using_cvode_) return
Dt = 1/steps_per_ms
nstep_steprun = int(Dt/dt)
if (nstep_steprun == 0) {
nstep_steprun = 1
}
dtnew = Dt/nstep_steprun
if (abs(dt*nstep_steprun*steps_per_ms - 1) > 1e-6) {
print "Changed dt"
dt = dtnew
}
}
//Setting the screen update interval
proc continuerun() {local rt, rtstart, ts
realtime = 0 rt = screen_update_invl rtstart = startsw()
eventcount=0
eventslow=1
stoprun = 0
if (using_cvode_) {
cvode.event($1)
ts = $1
if (cvode.use_local_dt) {
cvode.solve(ts)
flushPlot()
realtime = startsw() - rtstart
return
}
}else{
ts = $1 - dt/2
}
while(t < ts && stoprun == 0) {
step()
realtime = startsw() - rtstart
if (realtime >= rt) {
// if (!stdrun_quiet) fastflushPlot()
screen_update()
//really compute for at least screen_update_invl
realtime = startsw() - rtstart
rt = realtime + screen_update_invl
}
}
if (using_cvode_ && stoprun == 0) { // handle the "tstop" event
step() // so all recordings take place at tstop
}
flushPlot()
realtime = startsw() - rtstart
}
//Possibility to choose between the integration methods
proc cvode_act(){
if (isCVodeAct){
cvode.active(1)
print "Using variable time step integration method - faster simulation"
} else{
cvode.active(0)
print "Using fix time step integration method - slower simulation"
}
}
proc injSoma(){
isStim1 = 1
isStim2 = 0
stim1.amp = 0.1
stim2.amp = 0.02
stim3.amp = 0
stim4.amp = 0
}
proc injDend(){
isStim1 = 0
isStim2 = 1
access dend[47]{
stim3.loc(1)
stim4.loc(1)
}
stim1.amp = 0
stim2.amp = 0
stim3.amp = 0.1
stim4.amp = 0.02
}