// genesis /********************************************************************* ** The current equations themselves *********************************************************************/ float offset = 0.00 function make_Golgi_KA int i, cdivs float zinf, ztau, c, dc, cmin, cmax float x, dx, y float a, b /* The folowing variables are temporary (not temperature) variables used to speed up computations */ float mintau float max float tau float temp1 float temp2 /* K A-current fast transient potassium channel, following Bardoni and Belluzzi 1993 */ create tabchannel Gran_KA setfield Gran_KA Ek {EK} Gbar 3.67 Ik 0 Gk 0 Xpower 3 Ypower 1 \ Zpower 0 call Gran_KA TABCREATE X {tab_xdivs} {tab_xmin} {tab_xmax} x = {tab_xmin} - {offset} dx = ({tab_xmax} - {tab_xmin})/{tab_xdivs} openfile KA_a_max.test w openfile KA_a_tau.test w for (i = 0; i <= ({tab_xdivs}); i = i + 1) tau = 0.410 * ({exp {(- (x * 1e3 + 43.5) / 42.8)}}) + 0.167 max = 1 / (1 + {exp {((-46.7 - x * 1e3) / 19.8)}}) setfield Gran_KA X_A->table[{i}] {tau * 0.001} // 0.005} setfield Gran_KA X_B->table[{i}] {max} writefile KA_a_max.test {x} {getfield Gran_KA X_B->table[{i}]} writefile KA_a_tau.test {x} {getfield Gran_KA X_A->table[{i}]} x = x + dx end tweaktau Gran_KA X setfield Gran_KA X_A->calc_mode 1 X_B->calc_mode 1 closefile KA_a_max.test closefile KA_a_tau.test call Gran_KA TABCREATE Y {tab_xdivs} {tab_xmin} {tab_xmax} x = {tab_xmin} - {offset} openfile KA_i_max.test w openfile KA_i_tau.test w for (i = 0; i <= ({tab_xdivs}); i = i + 1) tau = 10.8 + 30 * x + \ 1 / (57.9 * {exp {x * 127}} + 134e-6 * {exp {- x * 59}}) max = 1 / (1 + {exp {((x * 1e3 + 78.8) / 8.4)}}) setfield Gran_KA Y_A->table[{i}] {tau * 0.001} // 0.0002} // correction for sec and for 37 deg C setfield Gran_KA Y_B->table[{i}] {max} writefile KA_i_max.test {x} {getfield Gran_KA Y_B->table[{i}]} writefile KA_i_tau.test {x} {getfield Gran_KA Y_A->table[{i}]} x = x + dx end tweaktau Gran_KA Y setfield Gran_KA Y_A->calc_mode 1 Y_B->calc_mode 1 closefile KA_i_max.test closefile KA_i_tau.test // call Gran_KA TABSAVE tabKA37.data end