//genesis
// modification MAEX 16/4/96
// mf_NMDA synchan removed (not used)
// pf_AMPA synchan added for selective normalization of mossy fiber and
// parallel fiber inputs
/**********************************************************************
This is a copy of the single-compartment Granule cell comp (CP, RM),
except for the inclusion of a nerstpotential object for calcium, which
is copied from the Purkinje cell model (EDS), and for the addition of
a spike generation object
********************************************************************/
/*********************************************************************/
/*function make_interneuron_comps (see make_Granule_comps) */
/*********************************************************************/
function make_Golgi_comps
/* separate function so we can have local variables */
float len, dia, surf, shell_vol, shell_dia
/* make spherical soma prototype with sodium currents*/
len = 0.00e-6
dia = 1
surf = dia*dia*{PI}
shell_dia = dia - 2*{Shell_thick}
shell_vol = (dia*dia*dia - shell_dia*shell_dia*shell_dia)*{PI}/6.0
create neutral interneuron
if (!({exists interneuron/soma}))
create compartment interneuron/soma
end
// F
// ohm, correct for sphere
// V
// V
// ohm
ce /library/interneuron
setfield soma Cm {{CM}*surf} Ra {8.0*{RA}/(dia*{PI})} \
Em {EREST_ACT} Vm {RESET_ACT} Rm {{RMs}/surf} inject 0.0 \
dia {dia} len {len}
// Now copy the channels and set maximal conductances */
if (!({exists soma/InNa}))
copy ../Gran_InNa soma/InNa
addmsg soma soma/InNa VOLTAGE Vm
addmsg soma/InNa soma CHANNEL Gk Ek
end
setfield soma/InNa Gbar {{GInNas}*surf}
if (!({exists soma/KDr}))
copy ../Gran_KDr soma/KDr
addmsg soma soma/KDr VOLTAGE Vm
addmsg soma/KDr soma CHANNEL Gk Ek
end
setfield soma/KDr Gbar {{GKDrs}*surf}
if (!({exists soma/KA}))
copy ../Gran_KA soma/KA
addmsg soma soma/KA VOLTAGE Vm
addmsg soma/KA soma CHANNEL Gk Ek
end
setfield soma/KA Gbar {{GKAs}*surf}
if (!({exists soma/CaHVA}))
copy ../Gran_CaHVA soma/CaHVA
addmsg soma soma/CaHVA VOLTAGE Vm
addmsg soma/CaHVA soma CHANNEL Gk Ek
end
setfield soma/CaHVA Gbar {{GCaHVAs}*surf}
if (!({exists soma/H}))
copy ../Gran_H soma/H
addmsg soma soma/H VOLTAGE Vm
addmsg soma/H soma CHANNEL Gk Ek
end
setfield soma/H Gbar {{GHs}*surf}
if (!({exists soma/Moczyd_KC}))
copy ../Moczyd_KC soma/Moczyd_KC
addmsg soma soma/Moczyd_KC VOLTAGE Vm
addmsg soma/Moczyd_KC soma CHANNEL Gk Ek
end
setfield soma/Moczyd_KC Gbar {{GMocs}*surf}
if (!({exists soma/mf_AMPA}))
copy ../AMPA soma/mf_AMPA
addmsg soma/mf_AMPA soma CHANNEL Gk Ek
addmsg soma soma/mf_AMPA VOLTAGE Vm
end
setfield soma/mf_AMPA gmax {{getfield soma/mf_AMPA gmax} * surf}
if (!({exists soma/pf_AMPA}))
copy ../AMPA soma/pf_AMPA
addmsg soma/pf_AMPA soma CHANNEL Gk Ek
addmsg soma soma/pf_AMPA VOLTAGE Vm
end
setfield soma/pf_AMPA gmax {{getfield soma/pf_AMPA gmax} * surf}
/*
if (!({exists soma/mf_NMDA}))
copy ../NMDA soma/mf_NMDA
addmsg soma/mf_NMDA soma/mf_NMDA/Mg_BLOCK CHANNEL Gk Ek
addmsg soma/mf_NMDA/Mg_BLOCK soma CHANNEL Gk Ek
addmsg soma soma/mf_NMDA/Mg_BLOCK VOLTAGE Vm
addmsg soma soma/mf_NMDA VOLTAGE Vm
end
setfield soma/mf_NMDA gmax {GNMDAs * surf}
*/
if (!({exists soma/GABAA}))
copy ../GABAA soma/GABAA
addmsg soma/GABAA soma CHANNEL Gk Ek
addmsg soma soma/GABAA VOLTAGE Vm
end
setfield soma/GABAA gmax {G_GABAAs * surf}
//lets keep it simple for now
if (!{exists soma/Ca_pool})
create Ca_concen soma/Ca_pool
addmsg soma/Ca_pool soma/Moczyd_KC CONCEN Ca
addmsg soma/CaHVA soma/Ca_pool I_Ca Ik
end
setfield soma/Ca_pool tau {CaTau} \
B {1.0/(2.0*96494*shell_vol*{PI}*100/2012.67)} \
Ca_base {CCaI} thick {Shell_thick}
// the volume of the Ca-pool may not change in this 1C model
// Possibility of modelling NMDA Ca influx (not done in Gabbiani et al.)
// Probably not worth the effort (yet).
if (!{exists soma/Ca_nernst})
create nernst soma/Ca_nernst
addmsg soma/Ca_pool soma/Ca_nernst CIN Ca
addmsg soma/Ca_nernst soma/CaHVA EK E
end
setfield soma/Ca_nernst Cin {CCaI} Cout {CCaO} valency {2} \
scale {1.0} T {37}
/*
create spikegen soma/spike
setfield soma/spike thresh 0 abs_refract 0.01 output_amp 1
addmsg soma soma/spike INPUT Vm
*/
end