//genesis /********************************************************************** ** Sets up active membrane Granule cell compartment prototypes ** and dendritic spine prototypes. ** Carl Piaf 7th December 1994 ** Uses Granule1M.p data file ** Synapses: NONE ** This is a copy of ** /bbf/haddock/carl/Genesis/Granule/True_sa_1_compt_L37/Gran_comp1.g, ** converted to Genesis 2 by RM ** changed soma to granule/soma on 16/4/96 ** Modified bt Reinoud Maex 10/95-4/96 ********************************************************************/ /*********************************************************************/ /*function make_Granule_comps */ /*********************************************************************/ function make_Granule_comps /* separate function so we can have local variables */ float len, dia, surf, shell_vol, shell_dia /* make spherical soma prototype with sodium currents*/ len = 0.00e-6 dia = 1 surf = dia*dia*{PI} shell_dia = dia - 2*{Shell_thick} shell_vol = (dia*dia*dia - shell_dia*shell_dia*shell_dia)*{PI}/6.0 // create neutral granule if (!({exists soma})) create compartment soma end // F // ohm, correct for sphere // V // V // ohm setfield soma Cm {{CM}*surf} Ra {8.0*{RA}/(dia*{PI})} \ Em {EREST_ACT} Vm {RESET_ACT} Rm {{RMs}/surf} inject 0.0 \ dia {dia} len {len} // Now copy the channels and set maximal conductances */ copy Gran_InNa soma/InNa addmsg soma soma/InNa VOLTAGE Vm addmsg soma/InNa soma CHANNEL Gk Ek setfield soma/InNa Gbar {{GInNas}*surf} copy Gran_KDr soma/KDr addmsg soma soma/KDr VOLTAGE Vm addmsg soma/KDr soma CHANNEL Gk Ek setfield soma/KDr Gbar {{GKDrs}*surf} copy Gran_KA soma/KA addmsg soma soma/KA VOLTAGE Vm addmsg soma/KA soma CHANNEL Gk Ek setfield soma/KA Gbar {{GKAs}*surf} copy Gran_CaHVA soma/CaHVA addmsg soma soma/CaHVA VOLTAGE Vm addmsg soma/CaHVA soma CHANNEL Gk Ek setfield soma/CaHVA Gbar {{GCaHVAs}*surf} copy Gran_H soma/H addmsg soma soma/H VOLTAGE Vm addmsg soma/H soma CHANNEL Gk Ek setfield soma/H Gbar {{GHs}*surf} copy Moczyd_KC soma/Moczyd_KC addmsg soma soma/Moczyd_KC VOLTAGE Vm addmsg soma/Moczyd_KC soma CHANNEL Gk Ek setfield soma/Moczyd_KC Gbar {{GMocs}*surf} copy AMPA soma/mf_AMPA setfield soma/mf_AMPA \ gmax {{getfield soma/mf_AMPA gmax} * surf} addmsg soma/mf_AMPA soma CHANNEL Gk Ek addmsg soma soma/mf_AMPA VOLTAGE Vm copy NMDA soma/mf_NMDA setfield soma/mf_NMDA \ gmax {{getfield soma/mf_NMDA gmax} * surf} addmsg soma/mf_NMDA soma/mf_NMDA/Mg_BLOCK CHANNEL Gk Ek addmsg soma/mf_NMDA/Mg_BLOCK soma CHANNEL Gk Ek addmsg soma soma/mf_NMDA/Mg_BLOCK VOLTAGE Vm addmsg soma soma/mf_NMDA VOLTAGE Vm copy GABAA soma/GABAA setfield soma/GABAA gmax {{getfield soma/GABAA gmax} * surf} addmsg soma/GABAA soma CHANNEL Gk Ek addmsg soma soma/GABAA VOLTAGE Vm copy GABAB soma/GABAB setfield soma/GABAB gmax {{getfield soma/GABAB gmax} * surf} addmsg soma/GABAB soma CHANNEL Gk Ek addmsg soma soma/GABAB VOLTAGE Vm //lets keep it simple for now if (!{exists soma/Ca_pool}) create Ca_concen soma/Ca_pool end setfield soma/Ca_pool tau {CaTau} \ B {1.0/(2.0*96494*shell_vol*{PI}*100/2012.67)} \ Ca_base {CCaI} thick {Shell_thick} // the volume of the Ca-pool may not change in this 1C model addmsg soma/Ca_pool soma/Moczyd_KC CONCEN Ca addmsg soma/CaHVA soma/Ca_pool I_Ca Ik // Possibility of modelling NMDA Ca influx (not done in Gabbiani et al.) // Probably not worth the effort (yet). end