TITLE Cerebellum Granule Cell Model leakage
COMMENT
Reference: Theta-Frequency Bursting and Resonance in Cerebellar Granule Cells:Experimental
Evidence and Modeling of a Slow K+-Dependent Mechanism
Egidio D'Angelo,Thierry Nieus,Arianna Maffei,Simona Armano,Paola Rossi,Vanni Taglietti,
Andrea Fontana and Giovanni Naldi
SAT: its a distributed mechanism with out any dynamic behaviour. Its just modified from Granular cell's leakage channel.
ENDCOMMENT
NEURON {
SUFFIX Ubc_TRP
NONSPECIFIC_CURRENT itrp
:USEION cAMP READ cAMPi VALENCE 0
USEION ca READ cai
USEION con_2c READ con_2ci VALENCE 1
RANGE etrp, gtrp, i, itrp, fcAMP, TonicTRP
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
v (mV)
gtrp = 4.18e-6 (mho/cm2)
celsius = 30 (degC)
etrp = 0 (mV)
fcAMP = 1
theta = 0 (1)
TonicTRP = 0.05
}
ASSIGNED {
cAMPi (mM)
cai (mM)
itrp (mA/cm2)
i (mA/cm2)
con_2ci (mM)
}
BREAKPOINT {
:printf("cai %g\n",cai)
if(con_2ci > 0.0075){
itrp = (gtrp*(v - etrp) * (1 + (3*con_2ci)))
}else {
itrp = 0 :gtrp*(v - etrp) *0.01
}
i = itrp
: printf("cAMPi: %g \t itrp: %g",cAMPi)
}