TITLE I-h channel from Magee 1998 for distal dendrites
NEURON {
SUFFIX h
NONSPECIFIC_CURRENT i
RANGE ghbar, vhalfl, eh, g
RANGE linf,taul
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
eh=-30. (mV)
ghbar=.0001 (mho/cm2)
vhalfl=-90 (mV)
vhalft=-75 (mV)
a0t=0.011 (/ms)
zetal=4 (1)
zetat=2.2 (1)
gmt=.4 (1)
q10=4.5
qtl=1
}
STATE {
l
}
ASSIGNED {
v (mV)
i (mA/cm2)
linf
taul
g (mho/cm2)
celsius (degC)
}
INITIAL {
rate(v)
l=linf
}
BREAKPOINT {
SOLVE states METHOD cnexp
g = ghbar*l
i = g*(v-eh)
}
DERIVATIVE states {
rate(v)
l' = (linf - l)/taul
}
FUNCTION alpl(v(mV)) {
alpl = exp(1e-3*zetal*(v-vhalfl)*9.648e4/(8.315*(273.16+celsius)))
}
FUNCTION alpt(v(mV)) {
alpt = exp(1e-3*zetat*(v-vhalft)*9.648e4/(8.315*(273.16+celsius)))
}
FUNCTION bett(v(mV)) {
bett = exp(1e-3*zetat*gmt*(v-vhalft)*9.648e4/(8.315*(273.16+celsius)))
}
PROCEDURE rate(v (mV)) { :callable from hoc
LOCAL a,qt
qt=q10^((celsius-33)/10)
a = alpt(v)
linf = 1/(1+ alpl(v))
taul = bett(v)/(qtl*qt*a0t*(1+a))
}