// FILE IN USE 10/12/2004 -- present /* Script to add synapses to GP model but not add channel clusters. Clusters are handled separately by the read_clusters.g file. Clusters are added to the compartments listed in {clusterfname}, while STN synapses are added to the compartments listed in {STNfilename}. GP$1_defaults has these two set to the same, so the default is to have clusters at all STN synapse locations. Users can overwrite either or both file names to change the locations of syns & clusters. STN synapse amplitudes are scaled according to the values in {STN_scale} */ randseed 78923456 int i, num float d,l,surf, scalefac, totscale, meanscale str stncompartment //create input element tree outside of the cell path if (!{exists /inputs}) create neutral /inputs end create neutral /inputs/STN num_STN = 0 // Get mean value of scale factors openfile {STN_scale} r scalefac = {readfile {STN_scale}} totscale = 0 num = 0 while (! {eof {STN_scale}}) totscale = {totscale} + {scalefac} num = {num} + 1 scalefac = {readfile {STN_scale}} end closefile {STN_scale} meanscale = {totscale} / {num} echo "totscale: " {totscale} echo "num: " {num} echo "meanscale: " {meanscale} //clear and open file to list compartment names of all excitatory synapses // File MUST NOT have any blank lines at the end, or function will fail. openfile {STNfilename} r stncompartment = {readfile {STNfilename}} openfile {STN_scale} r scalefac = {readfile {STN_scale}} //cycle through STN input compartments while (! {eof {STNfilename}}) num_STN = {num_STN} + 1 //Add AMPA synapses copy /library/AMPA {cellpath}/{stncompartment}/AMPA addmsg {cellpath}/{stncompartment}/AMPA \ {cellpath}/{stncompartment} CHANNEL Gk Ek addmsg {cellpath}/{stncompartment} \ {cellpath}/{stncompartment}/AMPA VOLTAGE Vm //get compartment parameters d = {getfield {cellpath}/{stncompartment} dia} l = {getfield {cellpath}/{stncompartment} len} surf = {d}*{l}*{PI} // scale synapse amplitude setfield {cellpath}/{stncompartment}/AMPA gmax {{G_AMPA}*{scalefac}/{meanscale}} echo "synapse " {stncompartment} ": " {getfield {cellpath}/{stncompartment}/AMPA gmax} //set up timetables create neutral /inputs/STN/{stncompartment} create timetable /inputs/STN/{stncompartment}/timetable if ({STN_rate} > 0) setfield /inputs/STN/{stncompartment}/timetable \ maxtime {rundur} act_val 1.0 method 2 \ meth_desc1 {1/{STN_rate}} meth_desc2 0.005 meth_desc3 3 call /inputs/STN/{stncompartment}/timetable TABFILL end //set up spikegen create spikegen /inputs/STN/{stncompartment}/spikegen setfield /inputs/STN/{stncompartment}/spikegen \ output_amp 1 thresh 0.5 //connect timetables to AMPA synapses if ({STN_rate} > 0) addmsg /inputs/STN/{stncompartment}/timetable \ /inputs/STN/{stncompartment}/spikegen INPUT activation addmsg /inputs/STN/{stncompartment}/spikegen \ {cellpath}/{stncompartment}/AMPA SPIKE end // get next compartment name stncompartment = {readfile {STNfilename}} scalefac = {readfile {STN_scale}} if ({eof {STN_scale}}) echo "eof scale" end end closefile {STNfilename} closefile {STN_scale} if ({num_STN} != {num}) echo "ERROR: number of scale factors doesn't match number of synapses." quit end