// Run "cpp -P filename > newfilename" to process this file. -CG
#define IF_PREPROCESSED str creator="This file is automatically generated by the cpp preprocessor."
// GENESIS SETUP FILE
IF_PREPROCESSED
// Load common CIP functions
include ../../common/CIPfuncs.g
// Modify CIP configuration options
defdatadir = "data"
tmpdir = "data"
destdir = "data"
compressdata = 1
savesnapshot = 1
saveItotal = 1
silent -1
//load variable parameter values from environment variable
str parrow = {read_env_params}
echo "Parameter row: " {parrow}
str readcompartment
// assign variables by reading from the parrow variable
include readGPparams.g
float cip = 0
// Now that all params have been established, create library objects.
// Intrinsic params should be left alone from this point forward.
include ../../common/make_GP_library.g
// filename based on the trial and pAcip parameters
str basefilename = "/brute_" @ {trialnum} @ "_trial"
dt = 1e-5
//set up clocks
setclock 0 {dt} // simulation
setclock 1 {1e-4} // output
rundur = 1 // simulation length
//load compartments with ion channels
readcell {"../../common/" @ {morph_name} @ ".p"} {cellpath} -hsolve
//set up current injection
create pulsegen /pulse
addmsg /pulse {cellpath}/soma INJECT output
//set up hines solver
setfield {cellpath} \
path {cellpath}/##[][TYPE=compartment] \
comptmode 1 \
chanmode 4 \
calcmode 0 \
outclock 1 \
storemode 1
call {cellpath} SETUP
setmethod 11
//add synapses to appropriate compartments
//include ../../common/read_STN_syns_nocluster
include ../../common/read_clusters
//include ../../common/read_striatum_syns_const_scaled
//include ../../common/add_pallidum_syns
// Do each cip run serially
// initialize CIP params
cip_init
str hstr
#define addsavefieldVm(path) \
hstr = {findsolvefield {cellpath} {cellpath}/path Vm}; \
addmsg {cellpath} /out_v SAVE {hstr}
// save some more voltages from this morphology
// choose dendritic tips and axonal tip
addsavefieldVm(p0b2[26])
addsavefieldVm(p0b1b2b2[8])
addsavefieldVm(p1b1b1b2b2b2[7])
addsavefieldVm(p1b1b2b1b1[7])
addsavefieldVm(p1b2b2[28])
addsavefieldVm(axIN[59])
include ../../common/snapshotGP
str snapshotname = "/brute_" @ {trialnum} @ ".save"
str defsnapshot = {defdatadir} @ {snapshotname}
fileexists = {ls {defsnapshot}}
if (fileexists != "0")
// doesn't exist, run spont sim, and take snapshot
// Run 1 sec to reach steady state or stable cycle
// and 1 sec for spontaneous firing with 0 pA cip
do_cip_run 0 1 1 2 {cellpath} {basefilename}
snapshotname = {tmpdir} @ {snapshotname}
take_snapshot
else
// exists
// If snapshot is in data/, first copy to /tmp/ and then use
cp {{defdatadir} @ {snapshotname}} {tmpdir}
snapshotname = {tmpdir} @ {snapshotname}
// still run the simulation unless the voltage trace also exists
do_cip_run 0 1 1 2 {cellpath} {basefilename}
end
// Run CIP simulations starting from snapshot point
do_cip_run -100 0 1 2 {cellpath} {basefilename} {snapshotname}
do_cip_run 40 0 1 0.5 {cellpath} {basefilename} {snapshotname}
do_cip_run 100 0 1 2 {cellpath} {basefilename} {snapshotname}
do_cip_run 200 0 1 0.5 {cellpath} {basefilename} {snapshotname}
// cleanup and finish
cip_finish