TITLE voltage- and temperature-sensitive Trek-1 channel
: a.k.a. KCNK2, K2p2.1
: *** voltage-independent mode; only temperature dependent ***
: Only steady state, no kinetics at all.
:
: written by Patricio Orio to resemble the figures from:
: Bockenhauer et al. (Nature Neurosci. 4(5):486-491(2001)),
: Kang et al. (J Physiol 564(1):103-116(2005)) and
: Maingret et al. (EMBO J. 19(11):2483-2491(2000))
NEURON {
SUFFIX trek1
USEION k READ ek WRITE ik
RANGE gkbar
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
}
PARAMETER {
gkbar = .005 (mho/cm2)
Pmin = 0.1 (1) :Temperature-independent leak
q10 = 5 (1)
Tm = 39 (degC)
}
ASSIGNED {
ek (mV)
celsius (degC)
ik (mA/cm2)
v (mV)
o
}
BREAKPOINT {
Ps()
ik = o * gkbar * (v - ek)
}
INITIAL {
o = Pmin + (1-Pmin)/(1+exp(-(celsius-Tm)*q10/10 (degC)))
ik = o * gkbar * (v - ek)
}
PROCEDURE Ps(){
o = Pmin + (1-Pmin)/(1+exp(-(celsius - Tm)*q10/10 (degC)))
}