/* Template file for a single compartment model of a thalamocortical neuron modified from the model described by Destexhe et al, 1995. Destexhe, A., Bal, T., McCormick, D.A. and Sejnowski, T.J. Ionic mechanisms underlying synchronized oscillations and propagating waves in a model of ferret thalamic slices. Journal of Neurophysiology 76: 2049-2070, 1996. See also http://www.cnl.salk.edu/~alain , http://cns.fmed.ulaval.ca */ begintemplate sTC // create a new template object public soma , kl create soma[1] // one compartment of about 29000 um2 soma { nseg = 1 diam = 96 L = 96 cm = 1 } objectvar kl proc init() { local v_potassium, v_sodium objectvar kl kl = new kleak() v_potassium = -100 // potassium reversal potential v_sodium = 50 // sodium reversal potential soma { diam = 96 // geometry L = 96 // so that area is about 29000 um2 nseg = 1 Ra = 100 insert pas // leak current e_pas = -70 // from Rinzel g_pas = 1e-5 kl.loc(0.5) // K-leak Erev_kleak = v_potassium kl.gmax = 0.004 // (uS) // conversion: x(uS) = x(mS/cm2)*29000e-8*1e3 // = x(mS/cm2) * 0.29 insert hh2 // Hodgin-Huxley INa and IK ek = v_potassium ena = v_sodium vtraub_hh2 = -25 // High threshold to simulated IA gnabar_hh2 = 0.09 gkbar_hh2 = 0.01 insert hcn2 // model for HCN2 current gbar_hcn2 = 0.01 // maximal conductance a_hcn2 = 40e-9 // cAMP concentration gca_hcn2 = 1 // relative conductance of the bound state shift_hcn2 = 48 // shift in voltage dependence } } endtemplate sTC