function [X, t] = RSDE_Nk_channel_varying_v(t_fin, X0, Dt, N, Vpath)
%%% INPUTS
% t_fin is final time of solution (ms)
% X0 is vector with proportion of channels in each state at beginning of
% the simulation (initial state of the channel), ordering of vector is as
% follows - X0=[n4 n3 n2 n1 n0]'
% Dt is the time step
% N is the number of channels
% Vpath is the voltage path (so V varies over time)
%%% OUTPUTS
% t is time
% X - X(:, i) is the proportion of channels in each state at time t(i)
%(ordering of X(:, i) the same as X0).
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
% Initialise size of outputs
Nstep = ceil(t_fin/Dt); % Number of steps of size Dt=T/N
X=zeros(5,Nstep+1); %solution for orignal langevin
t=zeros(Nstep+1,1);
% Initialise matrices for the RSDE
E=[1 0 0 0
-1 1 0 0
0 -1 1 0
0 0 -1 1
0 0 0 -1];
% Set up initial conditions
X(:, 1)=X0;
t(1)=0;
% Brownian increments (scaled with the time step)
dW = sqrt(Dt)*randn(4,Nstep);
% Main loop
for i=2:Nstep+1
% Set voltage to value at current time step
V=Vpath(i);
% Calculate transition rates at current timestep, as function of the voltag
an=(0.01*(10-V))/(exp((10-V)/10)-1);%original HH model
bn=0.125*exp(-V/80);%original HH model
% Calculate drift term
M=[-4*bn an 0 0 0
4*bn -(an+3*bn) 2*an 0 0
0 3*bn -(2*an+2*bn) 3*an 0
0 0 2*bn -(3*an+bn) 4*an
0 0 0 bn -4*an];
% Calculate diffusion term
Noi=[sqrt((an*X(2, i-1)+4*bn*X(1, i-1)))*dW(1, i-1)
sqrt((2*an*X(3, i-1)+3*bn*X(2, i-1)))*dW(2, i-1)
sqrt((3*an*X(4, i-1)+2*bn*X(3, i-1)))*dW(3, i-1)
sqrt((4*an*X(5, i-1)+bn*X(4, i-1)))*dW(4, i-1)];
% Calculate SDE without reflecting term, at next time step
Xnext=X(:, i-1)+(M*X(:, i-1))*Dt+(1/(sqrt(N)))*E*Noi;
% Check to see if point lies in correct domain
if min(Xnext)>=0 && max(Xnext)<=1
% Point lies in correct domain so set solution to be this value
X(:, i)=Xnext;
else
% Project X into the correct domain
X(:, i) = projsplx(Xnext);
end
% Update the time vector
t(i)=t(i-1)+Dt;
end