/*
* effective.h
*
*
* Created by Daniele Linaro on 5/2/10.
* Copyright 2009 __MyCompanyName__. All rights reserved.
*
*/
#ifndef EFFECTIVE
#define EFFECTIVE
#include "randlib.h"
#include <cstdlib>
#include <cstdio>
#include <ctime>
//#define EULER
#define EXACT
const int nstates = 8;
class effective {
public:
effective(long seed, double area, double gamma, double gbar) {
/*
* area [um^2] - gamma [pS] - gbar [S/cm^2]
*/
N = (int) ceil(10000 * (area*gbar/gamma));
printf("EFFECTIVE model>> the number of channels is %d.\n", N);
init(seed);
}
~effective() {
delete norm;
}
void init(long seed) {
// random number generator
norm = new NormalBM(0., 1., (ullong) seed);
setV(-65);
tend = 10;
dt = 0.001;
}
void setV(double Vm) {
v = Vm;
am = alpham();
bm = betam();
ah = alphah();
bh = betah();
}
void setTend(double Tend) { tend = Tend; }
void setDt(double Dt) { dt = Dt; }
double getVm() const { return v; }
double getTend() const { return tend; }
double getDt() const { return dt; }
int simulate();
private:
void rates();
void consistency();
double vtrap(double x, double y) const;
double alpham() const;
double betam() const;
double alphah() const;
double betah() const;
private:
int N; // number of channels
double m, h; // gating variables
double m_inf, h_inf; // steady states
double tau_m, tau_h; // time constants
double am, bm, ah, bh;
double v; // membrane potential
double tend; // total simulation time
double dt; // current time and integration step
NormalBM *norm;
double z[nstates-1], tau_z[nstates-1], noise_z[nstates-1], var_z[nstates-1];
#ifdef EXACT
double mu_z[nstates-1];
#endif
};
#endif