# maint_zip_y.gil - ZIP + GluR23Y during maintenance

include:   lltp.gil


#         name          value
define:   ind_time      10
define:   zip_dur       720
define:   zip_start     200
define:   zip_stop      "zip_start + zip_dur"
define:   y_dur         740
define:   y_start       zip_start
define:   y_stop        "y_start + y_dur"

#setCount  id          time        count      comment
setCount:  E1_A        ind_time    100        "stim"
setCount:  E1_I        ind_time      0        "stim"

# ZIP: Inhibit reactions catalyzed by unbound PKMZ... 

setInhib:  p_ph_ri     zip_start   1.0        "ZIP on"
setInhib:  p_ph_ba     zip_start   1.0        "ZIP on"
setInhib:  p-au-ai     zip_start   1.0        "ZIP on"

# ZIP: Inhibit reactions catalyzed by bound PKMZ... 

setInhib:  aip_ph_ri   zip_start   1.0        "ZIP on"
setInhib:  aip_ph_ba   zip_start   1.0        "ZIP on"

# When ZIP wears off, undo the catalysis inhibitions...

setInhib:  p_ph_ri     zip_stop    0.0        "ZIP off"
setInhib:  p_ph_ba     zip_stop    0.0        "ZIP off"
setInhib:  p-au-ai     zip_stop    0.0        "ZIP off"

setInhib:  aip_ph_ri   zip_stop    0.0        "ZIP off"
setInhib:  aip_ph_ba   zip_stop    0.0        "ZIP off"

# GluR2Y: block endocytosis
setInhib:  ba-ai-au    y_start     1.0
setInhib:  ba-aip-au   y_start     1.0
setInhib:  e2a-ai-au   y_start     1.0
setInhib:  e2a-aip-au  y_start     1.0

# When GluR23Y wears off, unblock endocytosis
setInhib:  ba-ai-au    y_stop      0.0
setInhib:  ba-aip-au   y_stop      0.0
setInhib:  e2a-ai-au   y_stop      0.0
setInhib:  e2a-aip-au  y_stop      0.0