// written by Gabriela Cirtala
// Heterogenous ion channel conductance density model
// This code corresponds to Branch 17 of the PC
// This code will automatically run for PF in [2:2:150] for 1.1CaP
// Generates many .dat files corresponding to each PF and each point at which the voltage is recorded (check Results folder)
// Shows the dendritic spike propagation (check at PF activation time)
// this code is based on the homogenous model proposed by Zang et al. (Zang 2021).
load_file("nrngui.hoc")
Default_Eleak = -65
membranecap = 0.64 /* specific membrane capacitance in uF cm^-2 */
membraneresist = 120236 /* specific membrane resistance in ohm cm^2 */
axialresist = 120 /* axial resistivity in ohm cm */
// Load the morphology file:
xopen("PurkinjeMorphology_allbr.nrn")
forsec "axon" delete_section() // Delete original axon and add a fake AIS
objref g2, b2,c2, distrx, distry, cdistry, p
forall {
insert pas e_pas=Default_Eleak /* Insert Leak everywhere */
insert hpkj // Ih inserted everywhere
insert ds
insert pk
}
AIS { g_pas=1/membraneresist Ra=axialresist cm=membranecap}
forsec spinydend {g_pas=5.3/membraneresist Ra=axialresist cm=5.3*membranecap}
forsec maindend {g_pas=1.2/membraneresist Ra=axialresist cm=1.2*membranecap}
forsec "soma" { g_pas=1/membraneresist Ra=axialresist cm=membranecap}
forsec maindend {insert cdp4N}
forsec alldend {
insert Kv3
gbar_Kv3 = 0.1512
vshift_Kv3 = 4
insert newCaP
pcabar_newCaP = 1.90e-4
vshift_newCaP =-5
insert CaT3_1
pcabar_CaT3_1 = 2.7e-5
insert mslo
gbar_mslo = 0.21504
insert SK2
gkbar_SK2 = 3.6000e-04
scal_SK2 = 1.0
ghbar_hpkj = 0.00036
insert Kv1
gbar_Kv1 = 0.002//*2
insert Kv4
gbar_Kv4 = 0.0252
insert Kv4s
gbar_Kv4s = 0.015
}
forsec spinydend {
insert cdp4Nsp
gkbar_SK2 = 3.6000e-04
scal_SK2 = 1.0
gbar_Kv4 = 0.0264
gbar_Kv4s = 0.015
ghbar_hpkj = 3.2400e-04
vshift_Kv4 = 0
gbar_Kv1 = 0.001
gbar_Kv3 = 0.1512
vshift_Kv3 = 0
pcabar_CaT3_1 = 1.0800e-04
pcabar_newCaP = 7.6000e-04
vshift_newCaP = -5
scale_cdp4Nsp = 3.5
gbar_mslo = 0.0896
insert abBK
gabkbar_abBK = 0.15
}
forsec branch1 {
insert cdp4Nsp
gkbar_SK2 = 3.6000e-04
scal_SK2 = 1.0
gbar_Kv4 = 0.0264
gbar_Kv4s = 0.015
ghbar_hpkj = 3.2400e-04
vshift_Kv4 = 0
gbar_Kv1 = 0.001
gbar_Kv3 = 0.1512
vshift_Kv3 = 0
pcabar_CaT3_1 = 1.0800e-04
pcabar_newCaP = 7.6000e-04
vshift_newCaP = -5
scale_cdp4Nsp = 3.5
gbar_mslo = 0.0896
insert abBK
gabkbar_abBK = 0.15
}
forsec branch2 {
insert cdp4Nsp
gkbar_SK2 = 3.6000e-04
scal_SK2 = 1.0
gbar_Kv4 = 0.0264
gbar_Kv4s = 0.015
ghbar_hpkj = 3.2400e-04
vshift_Kv4 = 0
gbar_Kv1 = 0.001
gbar_Kv3 = 0.1512
vshift_Kv3 = 0
pcabar_CaT3_1 = 1.0800e-04
pcabar_newCaP = 7.6000e-04
vshift_newCaP = -5
scale_cdp4Nsp = 3.5
gbar_mslo = 0.0896
insert abBK
gabkbar_abBK = 0.15
}
forsec branch3 {
insert cdp4Nsp
gkbar_SK2 = 3.6000e-04
scal_SK2 = 1.0
gbar_Kv4 = 0.0264
gbar_Kv4s = 0.015
ghbar_hpkj = 3.2400e-04
vshift_Kv4 = 0
gbar_Kv1 = 0.001
gbar_Kv3 = 0.1512
vshift_Kv3 = 0
pcabar_CaT3_1 = 1.0800e-04
pcabar_newCaP = 7.6000e-04
vshift_newCaP = -5
scale_cdp4Nsp = 3.5
gbar_mslo = 0.0896
insert abBK
gabkbar_abBK = 0.15
}
forsec branch4 {
insert cdp4Nsp
gkbar_SK2 = 3.6000e-04
scal_SK2 = 1.0
gbar_Kv4 = 0.0264
gbar_Kv4s = 0.015
ghbar_hpkj = 3.2400e-04
vshift_Kv4 = 0
gbar_Kv1 = 0.001
gbar_Kv3 = 0.1512
vshift_Kv3 = 0
pcabar_CaT3_1 = 1.0800e-04
pcabar_newCaP = 7.6000e-04
vshift_newCaP = -5
scale_cdp4Nsp = 3.5
gbar_mslo = 0.0896
insert abBK
gabkbar_abBK = 0.15
}
forsec branch5 {
insert cdp4Nsp
gkbar_SK2 = 3.6000e-04
scal_SK2 = 1.0
gbar_Kv4 = 0.0264*1.9
gbar_Kv4s = 0.015*1.9
ghbar_hpkj = 3.2400e-04
vshift_Kv4 = 0
gbar_Kv1 = 0.001
gbar_Kv3 = 0.1512
vshift_Kv3 = 0
pcabar_CaT3_1 = 1.0800e-04
pcabar_newCaP = 7.6000e-04
vshift_newCaP = -5
scale_cdp4Nsp = 3.5
gbar_mslo = 0.0896
insert abBK
gabkbar_abBK = 0.15
}
forsec branch6 {
insert cdp4Nsp
gkbar_SK2 = 3.6000e-04
scal_SK2 = 1.0
gbar_Kv4 = 0.0264*2.2
gbar_Kv4s = 0.015*2.2
ghbar_hpkj = 3.2400e-04
vshift_Kv4 = 0
gbar_Kv1 = 0.001
gbar_Kv3 = 0.1512
vshift_Kv3 = 0
pcabar_CaT3_1 = 1.0800e-04
pcabar_newCaP = 7.6000e-04
vshift_newCaP = -5
scale_cdp4Nsp = 3.5
gbar_mslo = 0.0896
insert abBK
gabkbar_abBK = 0.15
}
forsec branch7 {
insert cdp4Nsp
gkbar_SK2 = 3.6000e-04
scal_SK2 = 1.0
gbar_Kv4 = 0.0264*2.6
gbar_Kv4s = 0.015*2.6
ghbar_hpkj = 3.2400e-04
vshift_Kv4 = 0
gbar_Kv1 = 0.001
gbar_Kv3 = 0.1512
vshift_Kv3 = 0
pcabar_CaT3_1 = 1.0800e-04
pcabar_newCaP = 7.6000e-04
vshift_newCaP = -5
scale_cdp4Nsp = 3.5
gbar_mslo = 0.0896
insert abBK
gabkbar_abBK = 0.15
}
forsec branch8 {
insert cdp4Nsp
gkbar_SK2 = 3.6000e-04
scal_SK2 = 1.0
gbar_Kv4 = 0.0264*2.2
gbar_Kv4s = 0.015*2.2
ghbar_hpkj = 3.2400e-04
vshift_Kv4 = 0
gbar_Kv1 = 0.001
gbar_Kv3 = 0.1512
vshift_Kv3 = 0
pcabar_CaT3_1 = 1.0800e-04
pcabar_newCaP = 7.6000e-04*0.9
vshift_newCaP = -5
scale_cdp4Nsp = 3.5
gbar_mslo = 0.0896
insert abBK
gabkbar_abBK = 0.15
}
forsec branch9 {
insert cdp4Nsp
gkbar_SK2 = 3.6000e-04
scal_SK2 = 1.0
gbar_Kv4 = 0.0264
gbar_Kv4s = 0.015
ghbar_hpkj = 3.2400e-04
vshift_Kv4 = 0
gbar_Kv1 = 0.001
gbar_Kv3 = 0.1512
vshift_Kv3 = 0
pcabar_CaT3_1 = 1.0800e-04
pcabar_newCaP = 7.6000e-04
vshift_newCaP = -5
scale_cdp4Nsp = 3.5
gbar_mslo = 0.0896
insert abBK
gabkbar_abBK = 0.15
}
forsec branch10 {
insert cdp4Nsp
gkbar_SK2 = 3.6000e-04
scal_SK2 = 1.0
gbar_Kv4 = 0.0264
gbar_Kv4s = 0.015
ghbar_hpkj = 3.2400e-04
vshift_Kv4 = 0
gbar_Kv1 = 0.001
gbar_Kv3 = 0.1512
vshift_Kv3 = 0
pcabar_CaT3_1 = 1.0800e-04
pcabar_newCaP = 7.6000e-04
vshift_newCaP = -5
scale_cdp4Nsp = 3.5
gbar_mslo = 0.0896
insert abBK
gabkbar_abBK = 0.15
}
forsec branch11 {
insert cdp4Nsp
gkbar_SK2 = 3.6000e-04
scal_SK2 = 1.0
gbar_Kv4 = 0.0264*1.2
gbar_Kv4s = 0.015*1.2
ghbar_hpkj = 3.2400e-04
vshift_Kv4 = 0
gbar_Kv1 = 0.001
gbar_Kv3 = 0.1512
vshift_Kv3 = 0
pcabar_CaT3_1 = 1.0800e-04
pcabar_newCaP = 7.6000e-04
vshift_newCaP = -5
scale_cdp4Nsp = 3.5
gbar_mslo = 0.0896
insert abBK
gabkbar_abBK = 0.15
}
forsec branch12 {
insert cdp4Nsp
gkbar_SK2 = 3.6000e-04
scal_SK2 = 1.0
gbar_Kv4 = 0.0264*1.3
gbar_Kv4s = 0.015*1.3
ghbar_hpkj = 3.2400e-04
vshift_Kv4 = 0
gbar_Kv1 = 0.001
gbar_Kv3 = 0.1512
vshift_Kv3 = 0
pcabar_CaT3_1 = 1.0800e-04
pcabar_newCaP = 7.6000e-04*0.8
vshift_newCaP = -5
scale_cdp4Nsp = 3.5
gbar_mslo = 0.0896
insert abBK
gabkbar_abBK = 0.15
}
forsec branch13 {
insert cdp4Nsp
gkbar_SK2 = 3.6000e-04
scal_SK2 = 1.0
gbar_Kv4 = 0.0264*1.9
gbar_Kv4s = 0.015*1.9
ghbar_hpkj = 3.2400e-04
vshift_Kv4 = 0
gbar_Kv1 = 0.001
gbar_Kv3 = 0.1512
vshift_Kv3 = 0
pcabar_CaT3_1 = 1.0800e-04
pcabar_newCaP = 7.6000e-04
vshift_newCaP = -5
scale_cdp4Nsp = 3.5
gbar_mslo = 0.0896
insert abBK
gabkbar_abBK = 0.15
}
forsec branch14 {
insert cdp4Nsp
gkbar_SK2 = 3.6000e-04
scal_SK2 = 1.0
gbar_Kv4 = 0.0264
gbar_Kv4s = 0.015
ghbar_hpkj = 3.2400e-04
vshift_Kv4 = 0
gbar_Kv1 = 0.001
gbar_Kv3 = 0.1512
vshift_Kv3 = 0
pcabar_CaT3_1 = 1.0800e-04
pcabar_newCaP = 7.6000e-04
vshift_newCaP = -5
scale_cdp4Nsp = 3.5
gbar_mslo = 0.0896
insert abBK
gabkbar_abBK = 0.15
}
forsec branch15 {
insert cdp4Nsp
gkbar_SK2 = 3.6000e-04
scal_SK2 = 1.0
gbar_Kv4 = 0.0264
gbar_Kv4s = 0.015
ghbar_hpkj = 3.2400e-04
vshift_Kv4 = 0
gbar_Kv1 = 0.001
gbar_Kv3 = 0.1512
vshift_Kv3 = 0
pcabar_CaT3_1 = 1.0800e-04
pcabar_newCaP = 7.6000e-04
vshift_newCaP = -5
scale_cdp4Nsp = 3.5
gbar_mslo = 0.0896
insert abBK
gabkbar_abBK = 0.15
}
forsec branch16 {
insert cdp4Nsp
gkbar_SK2 = 3.6000e-04
scal_SK2 = 1.0
gbar_Kv4 = 0.0264
gbar_Kv4s = 0.015
ghbar_hpkj = 3.2400e-04
vshift_Kv4 = 0
gbar_Kv1 = 0.001
gbar_Kv3 = 0.1512
vshift_Kv3 = 0
pcabar_CaT3_1 = 1.0800e-04
pcabar_newCaP = 7.6000e-04
vshift_newCaP = -5
scale_cdp4Nsp = 3.5
gbar_mslo = 0.0896
insert abBK
gabkbar_abBK = 0.15
}
forsec branch17 {
insert cdp4Nsp
gkbar_SK2 = 3.6000e-04
scal_SK2 = 1.0
gbar_Kv4 = 0.0264
gbar_Kv4s = 0.015
ghbar_hpkj = 3.2400e-04
vshift_Kv4 = 0
gbar_Kv1 = 0.001
gbar_Kv3 = 0.1512
vshift_Kv3 = 0
pcabar_CaT3_1 = 1.0800e-04
pcabar_newCaP = 7.6000e-04*1.1
vshift_newCaP = -5
scale_cdp4Nsp = 3.5
gbar_mslo = 0.0896
insert abBK
gabkbar_abBK = 0.15
}
forsec branch18 {
insert cdp4Nsp
gkbar_SK2 = 3.6000e-04
scal_SK2 = 1.0
gbar_Kv4 = 0.0264*1.0
gbar_Kv4s = 0.015
ghbar_hpkj = 3.2400e-04
vshift_Kv4 = 0
gbar_Kv1 = 0.001
gbar_Kv3 = 0.1512
vshift_Kv3 = 0
pcabar_CaT3_1 = 1.0800e-04
pcabar_newCaP = 7.6000e-04
vshift_newCaP = -5
scale_cdp4Nsp = 3.5
gbar_mslo = 0.0896
insert abBK
gabkbar_abBK = 0.15
}
forsec branch19 {
insert cdp4Nsp
gkbar_SK2 = 3.6000e-04
scal_SK2 = 1.0
gbar_Kv4 = 0.0264*1.0
gbar_Kv4s = 0.015
ghbar_hpkj = 3.2400e-04
vshift_Kv4 = 0
gbar_Kv1 = 0.001
gbar_Kv3 = 0.1512
vshift_Kv3 = 0
pcabar_CaT3_1 = 1.0800e-04
pcabar_newCaP = 7.6000e-04
vshift_newCaP = -5
scale_cdp4Nsp = 3.5
gbar_mslo = 0.0896
insert abBK
gabkbar_abBK = 0.15
}
forsec branch20 {
insert cdp4Nsp
gkbar_SK2 = 3.6000e-04
scal_SK2 = 1.0
gbar_Kv4 = 0.0264*1.0
gbar_Kv4s = 0.015
ghbar_hpkj = 3.2400e-04
vshift_Kv4 = 0
gbar_Kv1 = 0.001
gbar_Kv3 = 0.1512
vshift_Kv3 = 0
pcabar_CaT3_1 = 1.0800e-04
pcabar_newCaP = 7.6000e-04
vshift_newCaP = -5
scale_cdp4Nsp = 3.5
gbar_mslo = 0.0896
insert abBK
gabkbar_abBK = 0.15
}
forsec branch21 {
insert cdp4Nsp
gkbar_SK2 = 3.6000e-04
scal_SK2 = 1.0
gbar_Kv4 = 0.0264
gbar_Kv4s = 0.015
ghbar_hpkj = 3.2400e-04
vshift_Kv4 = 0
gbar_Kv1 = 0.001
gbar_Kv3 = 0.1512
vshift_Kv3 = 0
pcabar_CaT3_1 = 1.0800e-04
pcabar_newCaP =7.6000e-04*0.8
vshift_newCaP = -5
scale_cdp4Nsp = 3.5
gbar_mslo = 0.0896
insert abBK
gabkbar_abBK = 0.15
}
forsec branch22 {
insert cdp4Nsp
gkbar_SK2 = 3.6000e-04
scal_SK2 = 1.0
gbar_Kv4 = 0.0264
gbar_Kv4s = 0.015
ghbar_hpkj = 3.2400e-04
vshift_Kv4 = 0
gbar_Kv1 = 0.001
gbar_Kv3 = 0.1512
vshift_Kv3 = 0
pcabar_CaT3_1 = 1.0800e-04
pcabar_newCaP = 7.6000e-04*0.8
vshift_newCaP = -5
scale_cdp4Nsp = 3.5
gbar_mslo = 0.0896
insert abBK
gabkbar_abBK = 0.15
}
access somaA
somaA distance(0,0.5)
forsec "soma" {
// INa & IK's at soma only
//for soma, I make it fire under dissociated condition. The firing properties is comparable with Bean's data
insert naRsg // INa + resurgent
gbar_naRsg = 0.03168
vshifta_naRsg = 0
vshiftk_naRsg = 0
vshifti_naRsg = -5
insert nap
gbar_nap = 1.4000e-04
insert pk
ena = 63
ghbar_hpkj = 1.0800e-04 // Default = 1
insert cdp20N_FD2
insert Kv3
gbar_Kv3 = 1.8
vshift_Kv3 = 4
insert Kv1
gbar_Kv1 = 0
insert newCaP
pcabar_newCaP = 1.9000e-04
kt_newCaP = 1
vshift_newCaP = -5
insert mslo
gbar_mslo = 0.8736
insert abBK
gabkbar_abBK = 0.3
insert SK2
gkbar_SK2 = 0.0075
}
AIS {
insert naRsg // INa + resurgent
gbar_naRsg = 0.56
vshifta_naRsg = 15
vshiftk_naRsg = 5
vshifti_naRsg = -5
insert nap
gbar_nap = 0.0023
insert CaT3_1
pcabar_CaT3_1 = 1.2800e-04
ena = 63
ghbar_hpkj = 1.0800e-04
insert cdpAIS
insert Kv3
gbar_Kv3 = 115.2
vshift_Kv3 = 4
insert Kv1
gbar_Kv1 = 0
insert newCaP
pcabar_newCaP = 0.00228
kt_newCaP = 1
vshift_newCaP = -5
insert mslo
gbar_mslo = 6
insert abBK
gabkbar_abBK = 1.05
insert SK2
gkbar_SK2 = 0.0278
}
objref patch_site
patch_site = new List()
ip = 0
forsec patch_list {
patch_site.append(new SectionRef())
}
celsius = 34
dt = 0.02
steps_per_ms = 1/dt
dtsim = 0.02
objref g2, b2,c2, distrm, distrd
xopen ("electrode.hoc")
xopen("distri.hoc") //voltage spatial distribution
proc clamp_cc() {
somaA {
stim1.del = 0
stim1.dur = 1000000
stim1.amp = $1
}
}
v_init = -70
// Define the length of our simulation:
tstop = 600
objref scalefile
scalefile=new File()
xopen("distri_synapse.hoc")
objref pc
pc = new ParallelContext()
//function farmed out to slave nodes
func distscale() {local key, errval, cu_id, fr_id, dend_id localobj parvec, returnlist
key = $1
cu_id = int($1/100000000)
fr_id = int(($1 - cu_id*100000000)/1000000)
site_id = int(($1 - cu_id*100000000-fr_id*1000000)/10000)
dend_id = int(($1 - cu_id*100000000-fr_id*1000000-site_id*10000)/100)
trial_id = $1 - cu_id*100000000-fr_id*1000000-site_id*10000-dend_id*100
returnlist = new List()
returnlist = calc_EPSP_single(cu_id,fr_id,site_id,dend_id,trial_id)
pc.pack(returnlist.o(0))
pc.pack(returnlist.o(1))
pc.pack(returnlist.o(2))
pc.pack(returnlist.o(3))
pc.pack(returnlist.o(4))
pc.pack(returnlist.o(5))
pc.pack(returnlist.o(6))
pc.pack(returnlist.o(7))
pc.pack(returnlist.o(8))
pc.pack(returnlist.o(9))
pc.pack(returnlist.o(10))
pc.pack(returnlist.o(11))
pc.pack(returnlist.o(12))
pc.pack(returnlist.o(13))
pc.pack(returnlist.o(14))
pc.pack(returnlist.o(15))
pc.pack(returnlist.o(16))
pc.pack(returnlist.o(17))
pc.pack(returnlist.o(18))
pc.pack(returnlist.o(19))
pc.pack(returnlist.o(20))
pc.pack(returnlist.o(21))
pc.pack(returnlist.o(22))
pc.pack(returnlist.o(23))
pc.pack(returnlist.o(24))
pc.pack(returnlist.o(25))
pc.post(key)
return key
}
objref aSynapseList[11]
obfunc calc_EPSP_single() {localobj outlist, currecord, integ_soma, br1,br14_dist,br14_prox,br14_dist2,br15_dist,br15_prox,br16_dist,br16_prox,br17_dist,br17_prox,br17_mid,br18_dist,br18_prox,br18_mid,br19_dist,br19_prox,br19_mid,br20_dist,br20_prox,br20_dist2,br21_dist,br21_prox,br21_mid,br22_dist,br22_prox,br22_dist2
//function to calculate the max deflection due to a single synapse
cu_id = $1
fr_id = $2
siteval = $3
synval= $4
tr_id = $5
curr = -0.4+(cu_id-1)*0.2
nlist = fr_id // in fact nlist can be multiple, make synapses firing at bursting
Npf = 2+(synval-1)*2 // Number of Parallel Fibers
for i = 1,nlist {aSynapseList[i-1] = new List() } // every time this will be initialized.
randomseed = cu_id*100000000+fr_id*1000000+siteval*10000 +synval*100 + tr_id
br1 = new SectionList()
patch_site.o(siteval-1).sec br1.subtree()
br1.remove(cf)
br1.unique()
if (siteval==12) {
br1 = new SectionList()
forsec "dendA1_001101100*" br1.append()
}
if (i==13) {
br1 = new SectionList()
forsec "dendA1_0011011100*" br1.append()
forsec "dendA1_0011011101*" br1.append()
}
for i = 1,nlist {aSynapseList[i-1] = distSyns(Npf,br1,randomseed)}
for i = 1,nlist {
for ii=1,aSynapseList[i-1].count() {
aSynapseList[i-1].object(ii-1).onset = 399 // Activation time of the PF
aSynapseList[i-1].object(ii-1).tau0 = 0.3
aSynapseList[i-1].object(ii-1).tau1 = 3
aSynapseList[i-1].object(ii-1).e = 0
aSynapseList[i-1].object(ii-1).gmax = 0.5e-3//
}
}
outlist=new List()
integ_soma = new Vector()
integ_soma.record(&somaA.v(0.5))
br14_dist = new Vector()
br14_dist.record(&dendA1_0110110.v(0.05))
br14_prox = new Vector()
br14_prox.record(&dendA1_0110.v(0.05))
br14_dist2 = new Vector()
br14_dist2.record(&dendA1_0111101.v(0.05)) //branch 14 - distal2
br15_dist = new Vector()
br15_dist.record(&dendA1_0101101101001.v(0.05))
br15_prox = new Vector()
br15_prox.record(&dendA1_01010.v(0.05))
br16_dist = new Vector()
br16_dist.record(&dendA1_010001000000.v(0.05))
br16_prox = new Vector()
br16_prox.record(&dendA1_01000.v(0.05))
br17_dist = new Vector()
br17_dist.record(&dendA1_01001011001100.v(0.05))
br17_prox = new Vector()
br17_prox.record(&dendA1_0100101.v(0.05))
br17_mid = new Vector()
br17_mid.record(&dendA1_0100101100.v(0.05))
br18_dist = new Vector()
br18_dist.record(&dendA1_0100110010.v(0.05))
br18_prox = new Vector()
br18_prox.record(&dendA1_010011.v(0.05))
br18_mid = new Vector()
br18_mid.record(&dendA1_01001101.v(0.05))
br19_dist = new Vector()
br19_dist.record(&dendA1_01001110001.v(0.05))
br19_prox = new Vector()
br19_prox.record(&dendA1_0100111.v(0.05))
br19_mid = new Vector()
br19_mid.record(&dendA1_0100111011.v(0.05))
br20_dist = new Vector()
br20_dist.record(&dendA1_010010001010.v(0.05))
br20_prox = new Vector()
br20_prox.record(&dendA1_01001000.v(0.05))
br20_dist2 = new Vector()
br20_dist2.record(&dendA1_01001000000111.v(0.05))
br21_dist = new Vector()
br21_dist.record(&dendA1_0100100100110110001.v(0.05))
br21_prox = new Vector()
br21_prox.record(&dendA1_010010010.v(0.05))
br21_mid = new Vector()
br21_mid.record(&dendA1_010010010101011.v(0.05))
br22_dist = new Vector()
br22_dist.record(&dendA1_0100100110000110.v(0.05))
br22_prox = new Vector()
br22_prox.record(&dendA1_010010011.v(0.05))
br22_dist2 = new Vector()
br22_dist2.record(&dendA1_01001001100001111.v(0.05))
clamp_cc(curr)
finitialize(v_init)
continuerun(tstop)
// Record vectors containing results for the soma and for different distal and proximal points on the branches situated on the right main division of the tree:
outlist.append(integ_soma)
outlist.append(br14_dist)
outlist.append(br14_prox)
outlist.append(br14_dist2)
outlist.append(br15_dist)
outlist.append(br15_prox)
outlist.append(br16_dist)
outlist.append(br16_prox)
outlist.append(br17_dist)
outlist.append(br17_prox)
outlist.append(br17_mid)
outlist.append(br18_dist)
outlist.append(br18_prox)
outlist.append(br18_mid)
outlist.append(br19_dist)
outlist.append(br19_prox)
outlist.append(br19_mid)
outlist.append(br20_dist)
outlist.append(br20_prox)
outlist.append(br20_dist2)
outlist.append(br21_dist)
outlist.append(br21_prox)
outlist.append(br21_mid)
outlist.append(br22_dist)
outlist.append(br22_prox)
outlist.append(br22_dist2)
return outlist
}
pc.runworker()
objref somavec,br14_distvec, br14_proxvec, br14_distvec2,br15_distvec, br15_proxvec, br15_distvec2,br16_distvec, br16_proxvec, br17_distvec, br17_proxvec, br17_midvec,br18_distvec, br18_proxvec, br18_midvec,br19_distvec, br19_proxvec, br19_midvec, br20_distvec, br20_proxvec, br20_distvec2, br21_distvec, br21_proxvec, br21_midvec,br22_distvec, br22_proxvec, br22_distvec2
somavec = new Vector()
br14_distvec = new Vector()
br14_proxvec = new Vector()
br14_distvec2 = new Vector()
br15_distvec = new Vector()
br15_proxvec = new Vector()
br16_distvec = new Vector()
br16_proxvec = new Vector()
br17_distvec = new Vector()
br17_proxvec = new Vector()
br17_midvec = new Vector()
br18_distvec = new Vector()
br18_proxvec = new Vector()
br18_midvec = new Vector()
br19_distvec = new Vector()
br19_proxvec = new Vector()
br19_midvec = new Vector()
br20_distvec = new Vector()
br20_proxvec = new Vector()
br20_distvec2 = new Vector()
br21_distvec = new Vector()
br21_proxvec = new Vector()
br21_midvec = new Vector()
br22_distvec = new Vector()
br22_proxvec = new Vector()
br22_distvec2 = new Vector()
strdef tmpstr
strdef outDir
strdef cmd
objref outfile
outfile = new File()
proc calcEPSPs() {
sprint(outDir,"Results")
sprint(cmd, "system(\"mkdir -p %s\")",outDir)
execute(cmd)
somaA distance(0,0.5)
for cu = 3, $1 {
for freq = 1, $2 {
for site = $3, $3 {
for m = 1, $4 {
for nt =$5 ,$5 {
mmtag=cu*100000000 + freq*1000000 + site*10000+m*100 + nt
pc.submit("distscale",mmtag) //send out the error calculations
}
}
}
}
}
//collect error values
while (pc.working()) {
key = pc.retval() //retrieve the tag
pc.look_take(key) //remove the tag/job from the bulletin
somavec = pc.upkvec() //unpack the error value associated with the tag
br14_distvec = pc.upkvec()
br14_proxvec = pc.upkvec()
br14_distvec2 = pc.upkvec()
br15_distvec = pc.upkvec()
br15_proxvec = pc.upkvec()
br16_distvec = pc.upkvec()
br16_proxvec = pc.upkvec()
br17_distvec = pc.upkvec()
br17_proxvec = pc.upkvec()
br17_midvec = pc.upkvec()
br18_distvec = pc.upkvec()
br18_proxvec = pc.upkvec()
br18_midvec = pc.upkvec()
br19_distvec = pc.upkvec()
br19_proxvec = pc.upkvec()
br19_midvec = pc.upkvec()
br20_distvec = pc.upkvec()
br20_proxvec = pc.upkvec()
br20_distvec2 = pc.upkvec()
br21_distvec = pc.upkvec()
br21_proxvec = pc.upkvec()
br21_midvec = pc.upkvec()
br22_distvec = pc.upkvec()
br22_proxvec = pc.upkvec()
br22_distvec2 = pc.upkvec()
print "received key ",key
cuno = int(key/100000000)
frno = int((key- cuno*100000000)/1000000)
siteno = int((key - cuno*100000000 - frno*1000000)/10000)
synno= int((key - cuno*100000000 - frno*1000000 - siteno*10000)/100)
trno = key - cuno*100000000-frno*1000000-siteno*10000-synno*100
sprint(tmpstr,"%s/%03d_%03d_%03d_%03d_%03d_vsoma.dat",outDir,cuno,frno,siteno,synno,trno)
outfile.wopen(tmpstr)
somavec.printf(outfile)
outfile.close()
sprint(tmpstr,"%s/%03d_%03d_%03d_%03d_%03d_vbr14_dist.dat",outDir,cuno,frno,siteno,synno,trno)
outfile.wopen(tmpstr)
br14_distvec.printf(outfile)
outfile.close()
sprint(tmpstr,"%s/%03d_%03d_%03d_%03d_%03d_vbr14_prox.dat",outDir,cuno,frno,siteno,synno,trno)
outfile.wopen(tmpstr)
br14_proxvec.printf(outfile)
outfile.close()
sprint(tmpstr,"%s/%03d_%03d_%03d_%03d_%03d_vbr14_dist2.dat",outDir,cuno,frno,siteno,synno,trno)
outfile.wopen(tmpstr)
br14_distvec2.printf(outfile)
outfile.close()
sprint(tmpstr,"%s/%03d_%03d_%03d_%03d_%03d_vbr15_dist.dat",outDir,cuno,frno,siteno,synno,trno)
outfile.wopen(tmpstr)
br15_distvec.printf(outfile)
outfile.close()
sprint(tmpstr,"%s/%03d_%03d_%03d_%03d_%03d_vbr15_prox.dat",outDir,cuno,frno,siteno,synno,trno)
outfile.wopen(tmpstr)
br15_proxvec.printf(outfile)
outfile.close()
sprint(tmpstr,"%s/%03d_%03d_%03d_%03d_%03d_vbr16_dist.dat",outDir,cuno,frno,siteno,synno,trno)
outfile.wopen(tmpstr)
br16_distvec.printf(outfile)
outfile.close()
sprint(tmpstr,"%s/%03d_%03d_%03d_%03d_%03d_vbr16_prox.dat",outDir,cuno,frno,siteno,synno,trno)
outfile.wopen(tmpstr)
br16_proxvec.printf(outfile)
outfile.close()
sprint(tmpstr,"%s/%03d_%03d_%03d_%03d_%03d_vbr17_dist.dat",outDir,cuno,frno,siteno,synno,trno)
outfile.wopen(tmpstr)
br17_distvec.printf(outfile)
outfile.close()
sprint(tmpstr,"%s/%03d_%03d_%03d_%03d_%03d_vbr17_prox.dat",outDir,cuno,frno,siteno,synno,trno)
outfile.wopen(tmpstr)
br17_proxvec.printf(outfile)
outfile.close()
sprint(tmpstr,"%s/%03d_%03d_%03d_%03d_%03d_vbr17_mid.dat",outDir,cuno,frno,siteno,synno,trno)
outfile.wopen(tmpstr)
br17_midvec.printf(outfile)
outfile.close()
sprint(tmpstr,"%s/%03d_%03d_%03d_%03d_%03d_vbr18_dist.dat",outDir,cuno,frno,siteno,synno,trno)
outfile.wopen(tmpstr)
br18_distvec.printf(outfile)
outfile.close()
sprint(tmpstr,"%s/%03d_%03d_%03d_%03d_%03d_vbr18_prox.dat",outDir,cuno,frno,siteno,synno,trno)
outfile.wopen(tmpstr)
br18_proxvec.printf(outfile)
outfile.close()
sprint(tmpstr,"%s/%03d_%03d_%03d_%03d_%03d_vbr18_mid.dat",outDir,cuno,frno,siteno,synno,trno)
outfile.wopen(tmpstr)
br18_midvec.printf(outfile)
outfile.close()
sprint(tmpstr,"%s/%03d_%03d_%03d_%03d_%03d_vbr19_dist.dat",outDir,cuno,frno,siteno,synno,trno)
outfile.wopen(tmpstr)
br19_distvec.printf(outfile)
outfile.close()
sprint(tmpstr,"%s/%03d_%03d_%03d_%03d_%03d_vbr19_prox.dat",outDir,cuno,frno,siteno,synno,trno)
outfile.wopen(tmpstr)
br19_proxvec.printf(outfile)
outfile.close()
sprint(tmpstr,"%s/%03d_%03d_%03d_%03d_%03d_vbr19_mid.dat",outDir,cuno,frno,siteno,synno,trno)
outfile.wopen(tmpstr)
br19_midvec.printf(outfile)
outfile.close()
sprint(tmpstr,"%s/%03d_%03d_%03d_%03d_%03d_vbr20_dist.dat",outDir,cuno,frno,siteno,synno,trno)
outfile.wopen(tmpstr)
br20_distvec.printf(outfile)
outfile.close()
sprint(tmpstr,"%s/%03d_%03d_%03d_%03d_%03d_vbr20_prox.dat",outDir,cuno,frno,siteno,synno,trno)
outfile.wopen(tmpstr)
br20_proxvec.printf(outfile)
outfile.close()
sprint(tmpstr,"%s/%03d_%03d_%03d_%03d_%03d_vbr20_distvec2.dat",outDir,cuno,frno,siteno,synno,trno)
outfile.wopen(tmpstr)
br20_distvec2.printf(outfile)
outfile.close()
sprint(tmpstr,"%s/%03d_%03d_%03d_%03d_%03d_vbr21_dist.dat",outDir,cuno,frno,siteno,synno,trno)
outfile.wopen(tmpstr)
br21_distvec.printf(outfile)
outfile.close()
sprint(tmpstr,"%s/%03d_%03d_%03d_%03d_%03d_vbr21_prox.dat",outDir,cuno,frno,siteno,synno,trno)
outfile.wopen(tmpstr)
br21_proxvec.printf(outfile)
outfile.close()
sprint(tmpstr,"%s/%03d_%03d_%03d_%03d_%03d_vbr21_mid.dat",outDir,cuno,frno,siteno,synno,trno)
outfile.wopen(tmpstr)
br21_midvec.printf(outfile)
outfile.close()
sprint(tmpstr,"%s/%03d_%03d_%03d_%03d_%03d_vbr22_dist.dat",outDir,cuno,frno,siteno,synno,trno)
outfile.wopen(tmpstr)
br22_distvec.printf(outfile)
outfile.close()
sprint(tmpstr,"%s/%03d_%03d_%03d_%03d_%03d_vbr22_prox.dat",outDir,cuno,frno,siteno,synno,trno)
outfile.wopen(tmpstr)
br22_proxvec.printf(outfile)
outfile.close()
sprint(tmpstr,"%s/%03d_%03d_%03d_%03d_%03d_vbr22_dist2.dat",outDir,cuno,frno,siteno,synno,trno)
outfile.wopen(tmpstr)
br22_distvec2.printf(outfile)
outfile.close()
}
}
calcEPSPs(3,1,17,75,1) // Here, 75 corresponds to Npf = 75x2 (the PF step) = 150PF.
//If you wish to change the total number of PF, just change this number to whatever you prefer.
// If you prefer to run for only one PF choice please change the following line inside of the proc calcESP:
// for m = 1, $4 ---> for m = $4, $4