This is the model associated with the paper Anderson WS, Kudela P, Cho J, Bergey GK, Franaszczuk PJ (2007) Studies of stimulus parameters for seizure disruption using neural network simulations. Biol Cybern 97:173-94 To use first type make in the HopkinsModel directory. Currently I'm (Stan Anderson) running it on a 32-bit 16-node cluster, also running an older Redhat version. I've been compiling it on a 64-bit machine, but in 32-bit mode, the 64-bit machine is running a newer Suse version. As far as the individual c-codes: mknode.c is the code that sets up the intracolumnar connections and produces a synapse table that is passed to each node. mklink.c is the code that sets up the extracolumnar connections, which produces an unsorted link table that undergoes further manipulations. This code also calculates which neurons in the simulation will undergo action potentials during a stimulation pulse. sublink.c assigns the previously computed extracolumnar links to specific neurons, and strips away intranodal links, turning that information into synaptic structures as created in mknode.c. Extranodal links (i.e. computer to computer) or maintained as link structures. link_sort.c sorts the link structures into an order more easily read by the simulation code. crl.c actually writes the link information into a file of link structures that is passed to each node. netclustwacnmdadiff.c is the main simulation code running on each node with the integration loop, and accounting of synaptic currents. clust_cn.c - handles communication via nodes via packet protocols (very slow in this setting) the lnet.h and clust_cn.h files are the most important header files, and most variables can be found here. mkpar.c enables the user to fill the parameter tables for each cell class in terms of individual channel kinetic properties. Version: 20111007 This version contains changes in the sublink.c file.