/* Created by Language version: 7.7.0 */
/* VECTORIZED */
#define NRN_VECTORIZED 1
#include <stdio.h>
#include <stdlib.h>
#include <math.h>
#include "scoplib_ansi.h"
#undef PI
#define nil 0
#include "md1redef.h"
#include "section.h"
#include "nrniv_mf.h"
#include "md2redef.h"
#if METHOD3
extern int _method3;
#endif
#if !NRNGPU
#undef exp
#define exp hoc_Exp
extern double hoc_Exp(double);
#endif
#define nrn_init _nrn_init__NaTg
#define _nrn_initial _nrn_initial__NaTg
#define nrn_cur _nrn_cur__NaTg
#define _nrn_current _nrn_current__NaTg
#define nrn_jacob _nrn_jacob__NaTg
#define nrn_state _nrn_state__NaTg
#define _net_receive _net_receive__NaTg
#define rates rates__NaTg
#define states states__NaTg
#define _threadargscomma_ _p, _ppvar, _thread, _nt,
#define _threadargsprotocomma_ double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt,
#define _threadargs_ _p, _ppvar, _thread, _nt
#define _threadargsproto_ double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt
/*SUPPRESS 761*/
/*SUPPRESS 762*/
/*SUPPRESS 763*/
/*SUPPRESS 765*/
extern double *getarg();
/* Thread safe. No static _p or _ppvar. */
#define t _nt->_t
#define dt _nt->_dt
#define gbar _p[0]
#define vshifth _p[1]
#define vshiftm _p[2]
#define slopeh _p[3]
#define slopem _p[4]
#define ina _p[5]
#define g _p[6]
#define m _p[7]
#define h _p[8]
#define ena _p[9]
#define mInf _p[10]
#define mTau _p[11]
#define mAlpha _p[12]
#define mBeta _p[13]
#define hInf _p[14]
#define hTau _p[15]
#define hAlpha _p[16]
#define hBeta _p[17]
#define Dm _p[18]
#define Dh _p[19]
#define v _p[20]
#define _g _p[21]
#define _ion_ena *_ppvar[0]._pval
#define _ion_ina *_ppvar[1]._pval
#define _ion_dinadv *_ppvar[2]._pval
#if MAC
#if !defined(v)
#define v _mlhv
#endif
#if !defined(h)
#define h _mlhh
#endif
#endif
#if defined(__cplusplus)
extern "C" {
#endif
static int hoc_nrnpointerindex = -1;
static Datum* _extcall_thread;
static Prop* _extcall_prop;
/* external NEURON variables */
/* declaration of user functions */
static void _hoc_rates(void);
static int _mechtype;
extern void _nrn_cacheloop_reg(int, int);
extern void hoc_register_prop_size(int, int, int);
extern void hoc_register_limits(int, HocParmLimits*);
extern void hoc_register_units(int, HocParmUnits*);
extern void nrn_promote(Prop*, int, int);
extern Memb_func* memb_func;
#define NMODL_TEXT 1
#if NMODL_TEXT
static const char* nmodl_file_text;
static const char* nmodl_filename;
extern void hoc_reg_nmodl_text(int, const char*);
extern void hoc_reg_nmodl_filename(int, const char*);
#endif
extern void _nrn_setdata_reg(int, void(*)(Prop*));
static void _setdata(Prop* _prop) {
_extcall_prop = _prop;
}
static void _hoc_setdata() {
Prop *_prop, *hoc_getdata_range(int);
_prop = hoc_getdata_range(_mechtype);
_setdata(_prop);
hoc_retpushx(1.);
}
/* connect user functions to hoc names */
static VoidFunc hoc_intfunc[] = {
"setdata_NaTg", _hoc_setdata,
"rates_NaTg", _hoc_rates,
0, 0
};
/* declare global and static user variables */
/* some parameters have upper and lower limits */
static HocParmLimits _hoc_parm_limits[] = {
0,0,0
};
static HocParmUnits _hoc_parm_units[] = {
"gbar_NaTg", "S/cm2",
"vshifth_NaTg", "mV",
"vshiftm_NaTg", "mV",
"ina_NaTg", "mA/cm2",
"g_NaTg", "S/cm2",
0,0
};
static double delta_t = 0.01;
static double h0 = 0;
static double m0 = 0;
/* connect global user variables to hoc */
static DoubScal hoc_scdoub[] = {
0,0
};
static DoubVec hoc_vdoub[] = {
0,0,0
};
static double _sav_indep;
static void nrn_alloc(Prop*);
static void nrn_init(_NrnThread*, _Memb_list*, int);
static void nrn_state(_NrnThread*, _Memb_list*, int);
static void nrn_cur(_NrnThread*, _Memb_list*, int);
static void nrn_jacob(_NrnThread*, _Memb_list*, int);
static int _ode_count(int);
static void _ode_map(int, double**, double**, double*, Datum*, double*, int);
static void _ode_spec(_NrnThread*, _Memb_list*, int);
static void _ode_matsol(_NrnThread*, _Memb_list*, int);
#define _cvode_ieq _ppvar[3]._i
static void _ode_matsol_instance1(_threadargsproto_);
/* connect range variables in _p that hoc is supposed to know about */
static const char *_mechanism[] = {
"7.7.0",
"NaTg",
"gbar_NaTg",
"vshifth_NaTg",
"vshiftm_NaTg",
"slopeh_NaTg",
"slopem_NaTg",
0,
"ina_NaTg",
"g_NaTg",
0,
"m_NaTg",
"h_NaTg",
0,
0};
static Symbol* _na_sym;
extern Prop* need_memb(Symbol*);
static void nrn_alloc(Prop* _prop) {
Prop *prop_ion;
double *_p; Datum *_ppvar;
_p = nrn_prop_data_alloc(_mechtype, 22, _prop);
/*initialize range parameters*/
gbar = 1e-05;
vshifth = 0;
vshiftm = 0;
slopeh = 6;
slopem = 6;
_prop->param = _p;
_prop->param_size = 22;
_ppvar = nrn_prop_datum_alloc(_mechtype, 4, _prop);
_prop->dparam = _ppvar;
/*connect ionic variables to this model*/
prop_ion = need_memb(_na_sym);
nrn_promote(prop_ion, 0, 1);
_ppvar[0]._pval = &prop_ion->param[0]; /* ena */
_ppvar[1]._pval = &prop_ion->param[3]; /* ina */
_ppvar[2]._pval = &prop_ion->param[4]; /* _ion_dinadv */
}
static void _initlists();
/* some states have an absolute tolerance */
static Symbol** _atollist;
static HocStateTolerance _hoc_state_tol[] = {
0,0
};
static void _update_ion_pointer(Datum*);
extern Symbol* hoc_lookup(const char*);
extern void _nrn_thread_reg(int, int, void(*)(Datum*));
extern void _nrn_thread_table_reg(int, void(*)(double*, Datum*, Datum*, _NrnThread*, int));
extern void hoc_register_tolerance(int, HocStateTolerance*, Symbol***);
extern void _cvode_abstol( Symbol**, double*, int);
void _NaTg_reg() {
int _vectorized = 1;
_initlists();
ion_reg("na", -10000.);
_na_sym = hoc_lookup("na_ion");
register_mech(_mechanism, nrn_alloc,nrn_cur, nrn_jacob, nrn_state, nrn_init, hoc_nrnpointerindex, 1);
_mechtype = nrn_get_mechtype(_mechanism[1]);
_nrn_setdata_reg(_mechtype, _setdata);
_nrn_thread_reg(_mechtype, 2, _update_ion_pointer);
#if NMODL_TEXT
hoc_reg_nmodl_text(_mechtype, nmodl_file_text);
hoc_reg_nmodl_filename(_mechtype, nmodl_filename);
#endif
hoc_register_prop_size(_mechtype, 22, 4);
hoc_register_dparam_semantics(_mechtype, 0, "na_ion");
hoc_register_dparam_semantics(_mechtype, 1, "na_ion");
hoc_register_dparam_semantics(_mechtype, 2, "na_ion");
hoc_register_dparam_semantics(_mechtype, 3, "cvodeieq");
hoc_register_cvode(_mechtype, _ode_count, _ode_map, _ode_spec, _ode_matsol);
hoc_register_tolerance(_mechtype, _hoc_state_tol, &_atollist);
hoc_register_var(hoc_scdoub, hoc_vdoub, hoc_intfunc);
ivoc_help("help ?1 NaTg /Users/agmccrei/Google Drive/HayLab/Microcircuit/Test_Ih_Integration/mod/x86_64/NaTg.mod\n");
hoc_register_limits(_mechtype, _hoc_parm_limits);
hoc_register_units(_mechtype, _hoc_parm_units);
}
static int _reset;
static char *modelname = "";
static int error;
static int _ninits = 0;
static int _match_recurse=1;
static void _modl_cleanup(){ _match_recurse=1;}
static int rates(_threadargsproto_);
static int _ode_spec1(_threadargsproto_);
/*static int _ode_matsol1(_threadargsproto_);*/
static int _slist1[2], _dlist1[2];
static int states(_threadargsproto_);
/*CVODE*/
static int _ode_spec1 (double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) {int _reset = 0; {
rates ( _threadargs_ ) ;
Dm = ( mInf - m ) / mTau ;
Dh = ( hInf - h ) / hTau ;
}
return _reset;
}
static int _ode_matsol1 (double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) {
rates ( _threadargs_ ) ;
Dm = Dm / (1. - dt*( ( ( ( - 1.0 ) ) ) / mTau )) ;
Dh = Dh / (1. - dt*( ( ( ( - 1.0 ) ) ) / hTau )) ;
return 0;
}
/*END CVODE*/
static int states (double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) { {
rates ( _threadargs_ ) ;
m = m + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / mTau)))*(- ( ( ( mInf ) ) / mTau ) / ( ( ( ( - 1.0 ) ) ) / mTau ) - m) ;
h = h + (1. - exp(dt*(( ( ( - 1.0 ) ) ) / hTau)))*(- ( ( ( hInf ) ) / hTau ) / ( ( ( ( - 1.0 ) ) ) / hTau ) - h) ;
}
return 0;
}
static int rates ( _threadargsproto_ ) {
double _lqt ;
_lqt = pow( 2.3 , ( ( 34.0 - 21.0 ) / 10.0 ) ) ;
if ( v == ( - 38.0 + vshiftm ) ) {
v = v + 0.0001 ;
}
mAlpha = ( 0.182 * ( v - ( - 38.0 + vshiftm ) ) ) / ( 1.0 - ( exp ( - ( v - ( - 38.0 + vshiftm ) ) / slopem ) ) ) ;
mBeta = ( 0.124 * ( - v + ( - 38.0 + vshiftm ) ) ) / ( 1.0 - ( exp ( - ( - v + ( - 38.0 + vshiftm ) ) / slopem ) ) ) ;
mTau = ( 1.0 / ( mAlpha + mBeta ) ) / _lqt ;
mInf = mAlpha / ( mAlpha + mBeta ) ;
if ( v == ( - 66.0 + vshifth ) ) {
v = v + 0.0001 ;
}
hAlpha = ( - 0.015 * ( v - ( - 66.0 + vshifth ) ) ) / ( 1.0 - ( exp ( ( v - ( - 66.0 + vshifth ) ) / slopeh ) ) ) ;
hBeta = ( - 0.015 * ( - v + ( - 66.0 + vshifth ) ) ) / ( 1.0 - ( exp ( ( - v + ( - 66.0 + vshifth ) ) / slopeh ) ) ) ;
hTau = ( 1.0 / ( hAlpha + hBeta ) ) / _lqt ;
hInf = hAlpha / ( hAlpha + hBeta ) ;
return 0; }
static void _hoc_rates(void) {
double _r;
double* _p; Datum* _ppvar; Datum* _thread; _NrnThread* _nt;
if (_extcall_prop) {_p = _extcall_prop->param; _ppvar = _extcall_prop->dparam;}else{ _p = (double*)0; _ppvar = (Datum*)0; }
_thread = _extcall_thread;
_nt = nrn_threads;
_r = 1.;
rates ( _p, _ppvar, _thread, _nt );
hoc_retpushx(_r);
}
static int _ode_count(int _type){ return 2;}
static void _ode_spec(_NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
ena = _ion_ena;
_ode_spec1 (_p, _ppvar, _thread, _nt);
}}
static void _ode_map(int _ieq, double** _pv, double** _pvdot, double* _pp, Datum* _ppd, double* _atol, int _type) {
double* _p; Datum* _ppvar;
int _i; _p = _pp; _ppvar = _ppd;
_cvode_ieq = _ieq;
for (_i=0; _i < 2; ++_i) {
_pv[_i] = _pp + _slist1[_i]; _pvdot[_i] = _pp + _dlist1[_i];
_cvode_abstol(_atollist, _atol, _i);
}
}
static void _ode_matsol_instance1(_threadargsproto_) {
_ode_matsol1 (_p, _ppvar, _thread, _nt);
}
static void _ode_matsol(_NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node* _nd; double _v; int _iml, _cntml;
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
v = NODEV(_nd);
ena = _ion_ena;
_ode_matsol_instance1(_threadargs_);
}}
extern void nrn_update_ion_pointer(Symbol*, Datum*, int, int);
static void _update_ion_pointer(Datum* _ppvar) {
nrn_update_ion_pointer(_na_sym, _ppvar, 0, 0);
nrn_update_ion_pointer(_na_sym, _ppvar, 1, 3);
nrn_update_ion_pointer(_na_sym, _ppvar, 2, 4);
}
static void initmodel(double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt) {
int _i; double _save;{
h = h0;
m = m0;
{
rates ( _threadargs_ ) ;
m = mInf ;
h = hInf ;
}
}
}
static void nrn_init(_NrnThread* _nt, _Memb_list* _ml, int _type){
double* _p; Datum* _ppvar; Datum* _thread;
Node *_nd; double _v; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v = _v;
ena = _ion_ena;
initmodel(_p, _ppvar, _thread, _nt);
}
}
static double _nrn_current(double* _p, Datum* _ppvar, Datum* _thread, _NrnThread* _nt, double _v){double _current=0.;v=_v;{ {
g = gbar * m * m * m * h ;
ina = g * ( v - ena ) ;
}
_current += ina;
} return _current;
}
static void nrn_cur(_NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node *_nd; int* _ni; double _rhs, _v; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
ena = _ion_ena;
_g = _nrn_current(_p, _ppvar, _thread, _nt, _v + .001);
{ double _dina;
_dina = ina;
_rhs = _nrn_current(_p, _ppvar, _thread, _nt, _v);
_ion_dinadv += (_dina - ina)/.001 ;
}
_g = (_g - _rhs)/.001;
_ion_ina += ina ;
#if CACHEVEC
if (use_cachevec) {
VEC_RHS(_ni[_iml]) -= _rhs;
}else
#endif
{
NODERHS(_nd) -= _rhs;
}
}
}
static void nrn_jacob(_NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node *_nd; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml];
#if CACHEVEC
if (use_cachevec) {
VEC_D(_ni[_iml]) += _g;
}else
#endif
{
_nd = _ml->_nodelist[_iml];
NODED(_nd) += _g;
}
}
}
static void nrn_state(_NrnThread* _nt, _Memb_list* _ml, int _type) {
double* _p; Datum* _ppvar; Datum* _thread;
Node *_nd; double _v = 0.0; int* _ni; int _iml, _cntml;
#if CACHEVEC
_ni = _ml->_nodeindices;
#endif
_cntml = _ml->_nodecount;
_thread = _ml->_thread;
for (_iml = 0; _iml < _cntml; ++_iml) {
_p = _ml->_data[_iml]; _ppvar = _ml->_pdata[_iml];
_nd = _ml->_nodelist[_iml];
#if CACHEVEC
if (use_cachevec) {
_v = VEC_V(_ni[_iml]);
}else
#endif
{
_nd = _ml->_nodelist[_iml];
_v = NODEV(_nd);
}
v=_v;
{
ena = _ion_ena;
{ states(_p, _ppvar, _thread, _nt);
} }}
}
static void terminal(){}
static void _initlists(){
double _x; double* _p = &_x;
int _i; static int _first = 1;
if (!_first) return;
_slist1[0] = &(m) - _p; _dlist1[0] = &(Dm) - _p;
_slist1[1] = &(h) - _p; _dlist1[1] = &(Dh) - _p;
_first = 0;
}
#if defined(__cplusplus)
} /* extern "C" */
#endif
#if NMODL_TEXT
static const char* nmodl_filename = "/Users/agmccrei/Google Drive/HayLab/Microcircuit/Test_Ih_Integration/mod/NaTg.mod";
static const char* nmodl_file_text =
":Reference :Colbert and Pan 2002\n"
"\n"
"NEURON {\n"
" SUFFIX NaTg\n"
" USEION na READ ena WRITE ina\n"
" RANGE gbar, g, ina, vshifth, vshiftm, slopeh, slopem\n"
"}\n"
"\n"
"UNITS {\n"
" (S) = (siemens)\n"
" (mV) = (millivolt)\n"
" (mA) = (milliamp)\n"
"}\n"
"\n"
"PARAMETER {\n"
" gbar = 0.00001 (S/cm2)\n"
" vshifth = 0 (mV)\n"
" vshiftm = 0 (mV)\n"
" slopeh = 6\n"
" slopem = 6\n"
"}\n"
"\n"
"ASSIGNED {\n"
" v (mV)\n"
" ena (mV)\n"
" ina (mA/cm2)\n"
" g (S/cm2)\n"
" mInf\n"
" mTau\n"
" mAlpha\n"
" mBeta\n"
" hInf\n"
" hTau\n"
" hAlpha\n"
" hBeta\n"
"}\n"
"\n"
"STATE {\n"
" m\n"
" h\n"
"}\n"
"\n"
"BREAKPOINT {\n"
" SOLVE states METHOD cnexp\n"
" g = gbar*m*m*m*h\n"
" ina = g*(v-ena)\n"
"}\n"
"\n"
"DERIVATIVE states {\n"
" rates()\n"
" m' = (mInf-m)/mTau\n"
" h' = (hInf-h)/hTau\n"
"}\n"
"\n"
"INITIAL{\n"
" rates()\n"
" m = mInf\n"
" h = hInf\n"
"}\n"
"\n"
"PROCEDURE rates(){\n"
" LOCAL qt\n"
" qt = 2.3^((34-21)/10)\n"
" \n"
" UNITSOFF\n"
" if(v == (-38+vshiftm)){\n"
" v = v+0.0001\n"
" }\n"
" mAlpha = (0.182 * (v- (-38+vshiftm)))/(1-(exp(-(v- (-38+vshiftm))/slopem)))\n"
" mBeta = (0.124 * (-v + (-38+vshiftm)))/(1-(exp(-(-v + (-38+vshiftm))/slopem)))\n"
" mTau = (1/(mAlpha + mBeta))/qt\n"
" mInf = mAlpha/(mAlpha + mBeta)\n"
"\n"
" if(v == (-66+vshifth)){\n"
" v = v + 0.0001\n"
" }\n"
"\n"
" hAlpha = (-0.015 * (v- (-66+vshifth)))/(1-(exp((v- (-66+vshifth))/slopeh)))\n"
" hBeta = (-0.015 * (-v +(-66+vshifth)))/(1-(exp((-v +(-66+vshifth))/slopeh)))\n"
" hTau = (1/(hAlpha + hBeta))/qt\n"
" hInf = hAlpha/(hAlpha + hBeta)\n"
" UNITSON\n"
"}\n"
;
#endif