: 2019: Ih current for thalamocortical neurons by Elisabetta Iavarone @ Blue Brain Project
: References: Budde et al. (minf), J Physiol, 1997, Huguenard and McCormick, J Neurophysiol, 1992 (taum)
NEURON {
SUFFIX TC_ih_Bud97
NONSPECIFIC_CURRENT ih
RANGE gh_max, g_h, i_rec
}
UNITS {
(S) = (siemens)
(mV) = (millivolt)
(mA) = (milliamp)
}
PARAMETER {
gh_max = 2.2e-5 (S/cm2)
e_h = -43.0 (mV)
celsius (degC)
q10 = 4 : Santoro et al., J. Neurosci. 2000
}
ASSIGNED {
v (mV)
ih (mA/cm2)
g_h (S/cm2)
mInf
mTau
tcorr : Add temperature correction
i_rec
}
STATE {
m
}
BREAKPOINT {
SOLVE states METHOD cnexp
g_h = gh_max*m
ih = g_h*(v-e_h)
i_rec = ih
}
DERIVATIVE states {
rates()
m' = (mInf-m)/mTau
}
INITIAL{
rates()
m = mInf
tcorr = q10^((celsius-34)/10) : EI: Recording temp. 34 C Huguenard et al.
}
UNITSOFF
PROCEDURE rates(){
mInf = 1/(1+exp((v+86.4)/11.2)) : Budde et al., 1997
mTau = (1/(exp(-14.59 - 0.086*v) + exp(-1.87 + 0.0701*v )))/tcorr : Huguenard et al., 1992
}
UNITSON