#include "iostream.h" //#include "../define.h" #include "../Neuron.h" #include "../Synapse.h" #include "../HHneuron/HHneuron.h" #include "modelNMDAsynapse.h" #include"../rk4.h" #include "NMDAsynapse.h" NMDAsynapse::NMDAsynapse():Synapse(){} NMDAsynapse::NMDAsynapse(Neuron *obj1,Neuron *obj2,double a,double b):Synapse(obj1,obj2,N_DIM,N_PAR) { Evalid=Isynvalid=0; xnew=new double[Dimno]; extra=new double[2]; x=new double[Parno]; dx=new double[Dimno]; parameter=new double[Parno]; extra[0]=extra[1]=0; x[0]=.005; parameter[0]=a; parameter[1]=0; parameter[2]=.385715; //.072; parameter[3]=.014285;//.0066; parameter[4]=2; parameter[5]=5; parameter[6]=1; parameter[7]=b; } NMDAsynapse::NMDAsynapse(Neuron *obj1,Neuron *obj2,double *a,double *b):Synapse(obj1,obj2,N_DIM,N_PAR) { Evalid=Isynvalid=0; int i; xnew=new double[Dimno]; extra=new double[2]; x=new double[Parno]; dx=new double[Dimno]; parameter=new double[Parno]; extra[0]=extra[1]=0; for(i=0;i<Dimno;i++) x[i]=a[i]; for(i=0;i<Parno;i++) //parameter 0 is the synaptic strength and parameter 1 is parameter[i]=b[i]; // Ereversal for the synapse,parameter 2 is Vth of NMDAsynapse } //parameter 3 is synaptic timescale for synapse NMDAsynapse::~NMDAsynapse() { delete x; delete dx; delete parameter; delete extra; delete xnew; } void NMDAsynapse::setvalues(Neuron *obj1, Neuron *obj2,double *a,double *b) { int i; Evalid=Isynvalid=0; source=obj1; target=obj2; source->axon.add(this); target->den.add(this); Dimno=N_DIM; Parno=N_PAR; xnew=new double[Dimno]; extra=new double[2]; x=new double[Parno]; dx=new double[Dimno]; parameter=new double[Parno]; extra[0]=extra[1]=0; for(i=0;i<Dimno;i++) x[i]=a[i]; for(i=0;i<Parno;i++) //parameter 0 is the synaptic strength and parameter 1 is parameter[i]=b[i]; } void NMDAsynapse::update(double timestep) { step(timestep,x,dx,parameter,extra,xnew,Dimno,&t,&modelNMDAsynapse); Isynvalid=1; } void NMDAsynapse::steptime() { assert(Isynvalid); for(int i=0;i<Dimno;i++) { x[i]=xnew[i]; } Evalid=Isynvalid=0; } void NMDAsynapse::getvol() { if(!Evalid) { extra=new double[2]; extra[1]=source->E(); } Evalid=1; } double NMDAsynapse::Isyn() { double Isync,B; B = 1. / (1 + .288 * parameter[6] * exp (-.062 * target->E())); Isync=-parameter[0]*x[0]*B*(target->E()-parameter[1]); return(Isync); } double NMDAsynapse::Calcium() { double Isync,B; B = 1. / (1 + .288 * parameter[6] * exp (-.062 * target->E())); Isync=-parameter[7]*x[0]*B*(target->E()-parameter[1]); return(Isync); } /* x[0]=the synaptic open channel probability parameter[0]=synaptic max cinductance parameter[1]=synaptic reversal potential parameter[2]= alpha term for rise time for open channel parameter[3]=beta term for fall time of open channel parameter[4]=Vp..the threshold for activation of open channel probability (default=2) parameter[5]=Kp---normalizing factor (default 5) parameter[6]=Mg conc......(default 1) */