//genesis //kleak-paired.g function make_kleak(path, gbar, vpath) str path float gbar float area if ({vpath} == "/rhab/vm") area={rhabSA}/{rhabcyls} else area = {getfield {path} SAout } end //echo {vpath} {area} create ligand2_chan {path}/kleak /* units are msec, nA, uS, mV */ setfield {path}/kleak \ k1f.min 300e-3 \ k1f.max 0.0 \ k1f.slope -20 \ k1f.v0 -20.0 \ k1f.in_exp_power 1 \ k1f.out_exp_power -1 \ k1f.in_exp_offset 0 \ k1f.out_exp_offset 1 \ k1b.min 0.8e-3 \ k1b.max 0.0 \ k1b.slope 10.0 \ k1b.v0 -23.0 \ k1b.in_exp_power 1 \ k1b.out_exp_power -1 \ k1b.in_exp_offset 0 \ k1b.out_exp_offset 1 \ k2f.min 3000e-3 \ k2f.max 0.0 \ k2f.slope -20 \ k2f.v0 -20.0 \ k2f.in_exp_power 1 \ k2f.out_exp_power -1 \ k2f.in_exp_offset 0 \ k2f.out_exp_offset 1 \ k2b.min 0.08e-3 \ k2b.max 0.0 \ k2b.slope 10.0 \ k2b.v0 -23.0 \ k2b.in_exp_power 1 \ k2b.out_exp_power -1 \ k2b.in_exp_offset 0 \ k2b.out_exp_offset 1 \ gamma.slope -20 \ gamma.min 0 \ gamma.max 0 \ gamma.in_exp_power 1 \ gamma.out_exp_power -1 \ gamma.in_exp_offset 0 \ gamma.out_exp_offset 1 \ delta.slope -20 \ delta.min 0 \ delta.max 0 \ delta.in_exp_power 1 \ delta.out_exp_power -1 \ delta.in_exp_offset 0 \ delta.out_exp_offset 1 \ Vr -85.0 \ rxn_ord1 1 \ rxn_ord2 1 \ cond_state 0 \ Gbar {gbar*area} end /********************************************************************/ function kleak_comp (vpath, capath, startcyl, endcyl, gbar) str vpath, capath int startcyl, endcyl float gbar int i for (i=startcyl; i<=endcyl; i=i+1) make_kleak {capath}[{i}] {gbar} {vpath} addmsg {capath}[{i}] {capath}[{i}]/kleak LIGAND Conc addmsg {vpath} {capath}[{i}]/kleak VOLTAGE Vm addmsg {capath}[{i}]/kleak {vpath} CHANNEL G Vr end end