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<body>Author: JM Bouteiller
Description:
Model from Erreger 2005 (Subunit-specific gating controls rat NR1NR2A and ...)
v01:
Only contains the kinetic scheme.
v02:
Added all components to calculate current (Mg, perm_Ca, etc.)
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<parameter metaid="kd2m" id="kd2m" name="kd2m" value="0.00101" units="per_msec" constant="true" />
<parameter metaid="ksp" id="ksp" name="ksp" value="0.23" units="per_msec" constant="true" />
<parameter metaid="ksm" id="ksm" name="ksm" value="0.178" units="per_msec" constant="true" />
<parameter metaid="kfp" id="kfp" name="kfp" value="3.14" units="per_msec" constant="true" />
<parameter metaid="kfm" id="kfm" name="kfm" value="0.174" units="pS" constant="true" />
<parameter metaid="g1" id="g1" name="g1" value="40" units="pS" constant="true" />
<parameter metaid="g2" id="g2" name="g2" value="247" units="pS" constant="true" />
<parameter metaid="Vrev" id="Vrev" name="Vrev" value="-0.7" units="mV" constant="true" />
<parameter metaid="alpha" id="alpha" name="alpha" value="0.01" units="dimensionless" constant="true" />
<parameter metaid="cond" id="cond" name="cond" value="0" units="pS" constant="false" />
<parameter metaid="Iunit" id="Iunit" name="Iunit" value="0" units="pA" constant="false" />
<parameter metaid="I" id="I" name="I" value="0" units="pA" constant="false" />
<parameter metaid="nbNMDAR" id="nbNMDAR" name="nbNMDAR" value="1" units="dimensionless" constant="true" />
<parameter metaid="Omg" id="Omg" name="Omg" value="0" units="pS" constant="false" />
<parameter metaid="Ica" id="Ica" name="Ica" value="0" units="pA" constant="false" />
<parameter metaid="perm_Ca" id="perm_Ca" name="perm_Ca" value="0.1" units="dimensionless" constant="true" />
</listOfParameters>
<listOfRules>
<assignmentRule metaid="CDMT00042" variable="Omg">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide />
<ci> RA2fs </ci>
<apply>
<plus />
<cn type="integer"> 1 </cn>
<apply>
<divide />
<apply>
<times />
<apply>
<exp />
<apply>
<times />
<cn type="integer"> -62 </cn>
<ci> Vm </ci>
<cn> 0.001 </cn>
</apply>
</apply>
<ci> Mg </ci>
</apply>
<cn> 3.57 </cn>
</apply>
</apply>
</apply>
</math>
</assignmentRule>
<assignmentRule metaid="CDMT00043" variable="cond">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus />
<ci> g1 </ci>
<apply>
<divide />
<apply>
<minus />
<ci> g2 </ci>
<ci> g1 </ci>
</apply>
<apply>
<plus />
<cn type="integer"> 1 </cn>
<apply>
<exp />
<apply>
<times />
<ci> alpha </ci>
<ci> Vm </ci>
<cn> 0.001 </cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</assignmentRule>
<assignmentRule metaid="CDMT00044" variable="Iunit">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times />
<ci> cond </ci>
<apply>
<minus />
<ci> Vm </ci>
<ci> Vrev </ci>
</apply>
<cn> 0.001 </cn>
<ci> Omg </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule metaid="CDMT00045" variable="I">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times />
<ci> Iunit </ci>
<ci> nbNMDAR </ci>
</apply>
</math>
</assignmentRule>
<assignmentRule metaid="CDMT00046" variable="Ica">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times />
<ci> I </ci>
<ci> perm_Ca </ci>
</apply>
</math>
</assignmentRule>
</listOfRules>
<listOfReactions>
<reaction metaid="re4" id="re4" reversible="true" fast="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="R" alias="sa1">
<celldesigner:linkAnchor position="E" />
</celldesigner:baseReactant>
<celldesigner:baseReactant species="Glu" alias="sa9">
<celldesigner:linkAnchor position="S" />
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="RA" alias="sa2">
<celldesigner:linkAnchor position="W" />
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection arm="0" index="0" value="unknown" />
<celldesigner:lineDirection arm="1" index="0" value="unknown" />
<celldesigner:lineDirection arm="2" index="0" value="unknown" />
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="0" num1="0" num2="0" tShapeIndex="0">0.015151515151512918,0.4392980437284233</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000" />
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00016" species="R" stoichiometry="1" constant="true">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa1</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00017" species="Glu" stoichiometry="1" constant="true">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa9</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00018" species="RA" stoichiometry="1" constant="true">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa2</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00019">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus />
<apply>
<times />
<cn type="integer"> 2 </cn>
<ci> kon </ci>
<ci> R </ci>
<ci> Glu </ci>
</apply>
<apply>
<times />
<ci> RA </ci>
<ci> koff </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="re5" id="re5" reversible="true" fast="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="RA" alias="sa2">
<celldesigner:linkAnchor position="E" />
</celldesigner:baseReactant>
<celldesigner:baseReactant species="Glu" alias="sa10">
<celldesigner:linkAnchor position="S" />
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="RA2" alias="sa3">
<celldesigner:linkAnchor position="W" />
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection arm="0" index="0" value="unknown" />
<celldesigner:lineDirection arm="1" index="0" value="unknown" />
<celldesigner:lineDirection arm="2" index="0" value="unknown" />
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="0" num1="0" num2="0" tShapeIndex="0">0.01580180449628621,0.4333781965006729</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000" />
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00020" species="RA" stoichiometry="1" constant="true">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa2</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00021" species="Glu" stoichiometry="1" constant="true">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa10</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00022" species="RA2" stoichiometry="1" constant="true">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa3</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00035">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus />
<apply>
<times />
<ci> RA </ci>
<ci> Glu </ci>
<ci> kon </ci>
</apply>
<apply>
<times />
<ci> RA2 </ci>
<cn type="integer"> 2 </cn>
<ci> koff </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="re6" id="re6" reversible="true" fast="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="RA2" alias="sa3">
<celldesigner:linkAnchor position="N" />
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="D1" alias="sa4">
<celldesigner:linkAnchor position="S" />
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown" />
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000" />
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00023" species="RA2" stoichiometry="1" constant="true">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa3</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00024" species="D1" stoichiometry="1" constant="true">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa4</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00036">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus />
<apply>
<times />
<ci> RA2 </ci>
<ci> kd1m </ci>
</apply>
<apply>
<times />
<ci> D1 </ci>
<ci> kd1p </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="re7" id="re7" reversible="true" fast="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="RA2" alias="sa3">
<celldesigner:linkAnchor position="S" />
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="D2" alias="sa5">
<celldesigner:linkAnchor position="N" />
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown" />
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000" />
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00025" species="RA2" stoichiometry="1" constant="true">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa3</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00026" species="D2" stoichiometry="1" constant="true">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa5</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00037">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus />
<apply>
<times />
<ci> RA2 </ci>
<ci> kd2p </ci>
</apply>
<apply>
<times />
<ci> D2 </ci>
<ci> kd2m </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="re8" id="re8" reversible="true" fast="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="RA2" alias="sa3">
<celldesigner:linkAnchor position="ENE" />
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="RA2f" alias="sa6">
<celldesigner:linkAnchor position="WSW" />
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown" />
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000" />
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00027" species="RA2" stoichiometry="1" constant="true">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa3</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00028" species="RA2f" stoichiometry="1" constant="true">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa6</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00038">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus />
<apply>
<times />
<ci> RA2 </ci>
<ci> kfp </ci>
</apply>
<apply>
<times />
<ci> RA2f </ci>
<ci> kfm </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="re9" id="re9" reversible="true" fast="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="RA2" alias="sa3">
<celldesigner:linkAnchor position="ESE" />
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="RA2s" alias="sa7">
<celldesigner:linkAnchor position="WNW" />
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown" />
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000" />
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00029" species="RA2" stoichiometry="1" constant="true">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa3</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00030" species="RA2s" stoichiometry="1" constant="true">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa7</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00039">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus />
<apply>
<times />
<ci> RA2 </ci>
<ci> ksp </ci>
</apply>
<apply>
<times />
<ci> RA2s </ci>
<ci> ksm </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="re10" id="re10" reversible="true" fast="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="RA2s" alias="sa7">
<celldesigner:linkAnchor position="ENE" />
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="RA2fs" alias="sa8">
<celldesigner:linkAnchor position="WSW" />
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown" />
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000" />
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00031" species="RA2s" stoichiometry="1" constant="true">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa7</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00032" species="RA2fs" stoichiometry="1" constant="true">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa8</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00040">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus />
<apply>
<times />
<ci> RA2s </ci>
<ci> kfp </ci>
</apply>
<apply>
<times />
<ci> RA2fs </ci>
<ci> kfm </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="re11" id="re11" reversible="true" fast="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="RA2f" alias="sa6">
<celldesigner:linkAnchor position="ESE" />
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="RA2fs" alias="sa8">
<celldesigner:linkAnchor position="WNW" />
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown" />
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000" />
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00033" species="RA2f" stoichiometry="1" constant="true">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa6</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00034" species="RA2fs" stoichiometry="1" constant="true">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa8</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00041">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus />
<apply>
<times />
<ci> RA2f </ci>
<ci> ksp </ci>
</apply>
<apply>
<times />
<ci> RA2fs </ci>
<ci> ksm </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
</listOfReactions>
</model>
</sbml>