TITLE Fast Sodium Channel
NEURON {
SUFFIX Naf
USEION na READ ena WRITE ina
RANGE gnafbar, ina, g, i
}
UNITS {
(mA) = (milliamp)
(mV) = (millivolt)
(S) = (siemens)
}
PARAMETER {
gnafbar =0.06 (mho/cm2) <0,1e9>
}
ASSIGNED {
v (mV)
ena (mv)
ina (mA/cm2)
i (mA/cm2)
g (S/cm2)
minf mtau
hinf htau
}
STATE {
m h
}
BREAKPOINT {
SOLVE states METHOD cnexp
g = gnafbar * m * m * m * h
i = g * (v - ena)
ina = i
}
INITIAL {
m = 0.001
h = 0.5829
}
DERIVATIVE states {
rates(v)
m' = (minf - m)/mtau
h' = (hinf - h)/htau
}
PROCEDURE rates(v(mV)) {LOCAL a, b
a = (-0.4*(v+49))/(exp(-(v+49)/5)-1)
b = (0.4*(v+25))/(exp((v+25)/5)-1)
mtau = 1/(a + b)
minf = a/(a + b)
htau = 30/(exp((v+60)/15)+exp(-(v+60)/16))
hinf = 1/(1+exp((v+58)/7))
}